Table 2: Questionnaire ratings at baseline, 3 months, 1-3 years and 5 years.

QLQ C-30 scale n a Mean SEM p-value (ANOVA)
Physical functioning
Baseline 197 96.3 0.73
3 months 204 94.9 0.8
1 year 197 95.1 0.80
2 194 95.3 0.71
3 187 94.4 0.77
5 years 166 93.9 0.89 0.109
Role functioning
Baseline 199 92.2 1.41
3 months 206 91.3 1.3
1 year 195 94.5 1.18
2 192 95.8 0.95
3 186 93.4 1.12
5 years 166 94.5 1.09 0.227
Emotional functioning
Baseline 199 78.9 1.37
3 months 206 87 1.11 0.000*
1 year 196 89.8 1.08
2 193 89.1 1.16
3 186 89.2 1.07
5 years 166 90.9 1.06 0.000*
Cognitive functioning
Baseline 199 90.1 1.03
3 months 208 90.4 0.85
1 year 197 90 0.97
2 193 89.7 0.99
3 186 89.4 1.01
5 years 167 90.3 1.09 0.979
Social functioning
Baseline 196 92.4 1.16
3 months 208 86.3 1.31 0.001*
1 year 196 88.1 1.42
2 192 91 1.19
3 186 90.8 1.64
5 years 165 92.2 1.22 0.003*
QOL, Global health status
Baseline 198 78.1 1.43
3 months 208 77 1.37
1 year 196 79.6 1.34
2 191 81.6 1.19
3 185 81.2 1.3
5 years 165 80.4 1.47 0.273
Fatigue
Baseline 199 10.3 1.17
3 months 205 12.2 1.09
1 year 194 11 1.07
2 192 12.1 1.15
3 186 12.8 1.16
5 years 166 12.5 1.22 0.328
Nausea and vomiting
Baseline 199 1.3 0.47
3 months 205 0.7 0.25
1 year 195 0.5 0.2
2 192 1.2 0.4
3 186 1 0.35
5 years 166 2.3 0.76 0.074
Pain
Baseline 199 9.5 1.38
3 months 207 7.5 1.19
1 year 196 7.1 1.22
2 193 7.7 1.13
3 186 6.5 1.14
5 years 166 7.7 1.24 0.482
Single item scales Dyspnoea
Baseline 198 12.1 1.51
3 months 205 10.4 1.24
1 year 195 12.5 1.37
2 192 12.2 1.38
3 184 12.3 1.5
5 years 165 13.1 1.48 0.389
Sleep
Baseline 199 17.3 1.81
3 months 205 13.8 1.56
1 year 195 13.7 1.67
2 192 13.7 1.72
3 186 14.3 1.6
5 years 166 14.7 1.81 0.324
Appetite
Baseline 199 2.5 1.71
3 months 204 1.3 0.45
1 year 195 1.9 0.55
2 192 3.0 0.81
3 186 1.8 0.61
5 years 166 1.4 0.59 0.272
Constipation
Baseline 199 2.8 0.85
3 months 206 2.9 0.83
1 year 196 4.1 0.95
2 193 2.2 0.94
3 186 3.6 0.91
5 years 166 4.4 1.08 0.416
Diarrhoea
Baseline 198 1.0 0.80
3 months 206 4.3 0.88
1 year 196 4.0 0.82
2 193 5.0 1.01
3 186 4.8 0.97
5 years 166 3.8 1.12 0.894
Economy
Baseline 195 1.0 0.48
3 months 208 3.5 0.84 0.028*
1 year 196 2.4 0.70
2 191 1.6 0.51
3 186 2.2 0.66
5 years 166 2.0 0.68 0.387*
PR-25 scale N Mean SEM p-value (ANOVA)
Functional scales Sexual activity
Baseline 165 48.4 2.25
3 months 189 43.4 3.36
1 year 174 38.7 2.21
2 180 39.1 2.02
3 169 39.5 2.46
5 years 149 40.4 4.26 0.252
Sexual functioning
Baseline 124 84.1 1.67
3 months 105 42.9 2.25 0.000*
1 year 102 47.6 2.86
2 112 50.6 2.34
3 103 50.2 2.5
5 years 88 56.7 2.8 0.000*
Symptom scales Urinary symptoms
Baseline 170 17.1 1.26
3 months 195 18.8 1.01
1 year 183 15.1 0.92
2 186 14.8 1.05
3 176 15.6 1.23
5 years 162 16.2 1.28 0.286*
Bowel symptoms
Baseline 123 4.1 0.91
3 months 166 2.1 0.38
1 year 146 3 0.55
2 147 4.3 0.74
3 143 5.8 1.46
5 years 132 4.5 0.91 0.057
Hormone treatment- related symptoms
Baseline 166 6.2 0.72
3 months 188 11 0.64 0.000*
1 year 176 11.8 0.91
2 179 11.1 0.85
3 173 11.8 0.86
5 years 149 9.5 0.85 0.006*
Single item scale Incontinence aid
Baseline 10 13.3 5.44
3 months 80 22.9 3.23
1 year 43 17.1 4.2
2 39 17.1 3.21
3 40 11.7 3.28
5 years 38 11.4 2.89 0.058

* When significant ANOVA-test, the Bonferroni post hoc analysis was used
a Internal drop-outs: EORTC QLQ C-30, 1-26; PR 25, 27- 212.