Table 2: Renin-angiotensin system components in lens, tears and lacrimal gland, vitreous, optic nerve head and sclera of the human eye.

RAS component Lens Tears/Lacrimal gland Vitreous Optic nerve head Sclera References
Prorenin x x [24, 105, 107]
Renin x x [24, 105]
AGT x x [105, 110]
ACE1 x x x x [105, 112, 114, 115, 124-127]
ACE2
Ang I x [117]
Ang II x x [111, 119]
Ang(1–7)
(P)RR x [105]
AT, unknown subtype
AT1R x [119]
AT2R x [119]
AT4R
MasR

Table modified and updated from the table published by Holappa et al. [123]. ACE1, -2: Angiotensin converting enzyme 1, -2; AGT: Angiotensinogen; Ang I, -II: Angiotensin I, -II; Ang(1–7): Angiotensin (1–7); AT1R, -2R, -4R: Angiotensin II type 1, 2, 4 receptor; MasR: Mas receptor; (P)RR: (pro)renin receptor; RAS: Renin-angiotensin system.