Table 2: Characteristics of the Studies assessing Obesity as a Risk Factor

Author (year) Design Sample (n) Age (m±sd) Male Sex n (%) Main characteristics relating to obesity Outcome(s) Result(s)
Saw et al.
(2002) [42]
CS 1449 8 (±1) 746 (51.5) BMI (quartiles) Refraction Weight related to hypermetropy boys
Height related to myopia
Akinci et al. (2007) [35] Case-control 72 (BMI >95)
72 (BMI <95)
Group I Boys 13.7 (2.6)
Girls 14.6(1.8)
Group C
Boys 13.6(2.7)
Girls 14.5(1.9)
>0.05
49 (68) BMI >95th percentile Exophtham (Hertel)
IOP (applanation)
18% obese with exophthalmia
IOP not associated with blood pressure levels
10% obese with increased IOP
Cheung et al. (2007) [22] CS 768 7.9±0.8 403 (52.5) BMI (quartiles) Quantitative analysis of vessel caliber during retinography RAC: not associated
RVC: increased (every 3.1 kg/m2 BMI increases vein 2.55μ)
Gopinath et al. (2011) [24] CS 2353 12.7 ± 0.4 1188 (50.5) BMI (IOTF) Quantitative analysis of vessel caliber during retinography RAC: decreased
RVC: increased
Li et al. (2011) [43] CS 136 11.19 ± 2.5 69 (50.1) BMI > 85% percentile
Triceps skin fold
Quantitative analysis of vessel caliber during retinography RAC: not associated
RVC: increased
Albuquerque et al (2013) [44] CS 96 11 ± 2.8 46 (48) BMI ≥ 95% percentile IOP (applanation) IOP not associated
Jiang et al.
(2014) [46]
CS 5919 10.0±3.3 3118
(52.7)
BMI IOP (non-contact) IOP associate with BMI in boys
Kurniawan et al. (2014) [47] Cohort 421 11.9 ± 0.8 207 (49.2) BMI (WHO) Refraction +
Quantitative analysis of vessel caliber during retinography
SE (D): -2.23±1.4
RAC: no relationship
RVC: increased
Yau et al.
(2014) [6]
CS 39 cases
51 controls
17.8 ±1.6 15 (38.4) IR (QUICKI) Quantitative analysis of vessel caliber during retinography RAC: decreased
RVC: increased
Gishti et al. (2015) [45] CS 4145 6.0 +- 0.3 2072 (50) BMI ≥ 95% percentile Quantitative analysis of vessel caliber during retinography RAC decreased
RVC not related
Xiao et al.
(2015) [25]
CS 731 Subgroup 1:
7-11 y
Girls 9.4±1.2
Boys
9.62±1.36
Subgroup 2: 12-19 a
Girls 14.5±2
Boys 14.3±2.4
339 (46.3) BMI Quantitative analysis of vessel caliber during retinography RAC and RVC: between 12-19 years narrowing related to adiposity

AP= arterial pressure, BMI= body mass index, IOP= intraocular pressure, IOTF= International Obesity Task Force, IR (QUICKI) = index of resistance to insulin and method, RAC= retinal arteriolar caliber, RVC= retinal venular caliber, WHO= World Health Organization, sd= standard deviation, CS= cross-sectional, Exophtham = exophthalmometry