Table 2: Top 44 differentially expressed genes in orbital adipose tissue in severe, active TED.

Gene Symbol Gene Description Fold Change P Value FDR_BH
                        Downregulated Genes
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor] -4.18 1.46E-10 3.90E-07
ALX1 ALX homeobox 1 -3.16 2.74E-10 6.03E-07
LOC1004211 SEC24 family member A pseudogene -2.26 2.71E-10 6.03E-07
LINC01139 long intergenic non-proiein coding RNA 1139 -4.29 2.55E-09 4.68E-06
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -3.93 2.28E-08 2.31E-05
                        Upregulated Genes
PKD1P5 polycystic kidney disease 1 (autosomal dominant) pseudogene 5 5.50 3.31E-29 1.24E-24
S100A9 S100 calcium binding protein A9 8.82 7.40E-19 1.39E-14
SIRPB1 signal-regulatory protein beta 1 6.09 1.43E-15 1.78E-11
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.89 4.05E-15 3.79E-11
HCK hemopoietic cell kinase 3.72 1.53E-14 1.15E-10
FPR2 formyl peptide receptor 2 6.47 1.28E-13 7.99E-10
ALOX5 arachidonate 5-lipoxygenase 4.18 3.63E-13 1.94E-09
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 5.37 6.35E-12 2.64E-08
FPR1 formyl peptide receptor 1 5.48 1.26E-11 4.70E-08
RUBCNL RUN and cysteine rich domain containing beclin 1 interacting protein like 3.03 4.88E-11 1.52E-07
LRRC25 leucine rich repeat containing 25 3.48 9.73E-11 2.80E-07
HBG1 hemoglobin, gamma A 4.99 2.12E-10 5.29E-07
TGFA transforming growth factor, alpha 3.42 1.72E-09 3.58E-06
VCAN versican 3.06 2.75E-09 4.68E-06
CD300A CD300a molecule 3.37 2.73E-09 4.68E-06
CD52 CD52 molecule 3.41 2.40E-09 4.68E-06
CORO1A coronin, actin binding protein, 1A 3.19 3.27E-09 5.32E-06
SASH3 SAM and SH3 domain containing 3 2.99 5.09E-09 7.64E-06
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.40 7.95E-09 1.15E-05
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.06 8.94E-09 1.24E-05
EMR2 egf-like module containing, mucin-like, hormone receptor-like 2 3.48 9.40E-09 1.26E-05
LILRA5 leukocyte immunoglobulin like receptor A5 4.14 1.07E-08 1.38E-05
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) 3.52 1.31E-08 1.64E-05
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 3.71 1.38E-08 1.67E-05
CCL2 chemokine (C-C motif) ligand 2 3.83 1.50E-08 1.76E-05
MEFV Mediterranean fever 4.00 1.66E-08 1.88E-05
CYTIP cytohesin 1 interacting protein 4.18 1.77E-08 1.95E-05
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.95 2.08E-08 2.23E-05
NCF4 neutrophil cytosolic factor 4, 40kDa 2.23 2.15E-08 2.23E-05
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 3.91 2.56E-08 2.52E-05
ACTA2-AS1 ACTA2 antisense RNA 1 2.46 4.29E-08 4.12E-05
LYN LYN proto-oncogene, Src family tyrosine kinase 2.82 7.13E-08 6.68E-05
DDIT4 DNA-damage-inducible transcript 4 2.01 9.24E-08 7.95E-05
FERMT3 fermitin family member 3 2.55 9.03E-08 7.95E-05
NNMT nicotinamide N-methyltransferase 3.56 9.04E-08 7.95E-05
FFAR2 free fatty acid receptor 2 3.82 9.50E-08 7.95E-05
MMP25 matrix metallopeptidase 25 3.88 9.55E-08 7.95E-05
RBM47 RNA binding motif protein 47 2.81 1.18E-07 9.38E-05
STXBP2 syntaxin binding protein 2 3.08 1.18E-07 9.38E-05