Fig. (3) Schematic of retina and choroid (A) normal retina with intact RPE layer; (B) presence of drusen between RPE layer and Bruch's membrane during dry AMD and inducement of production of VEGF; (C) formation of abnormal new blood vessels by VEGF in choroid (CNV), disturbance of integrity of Bruch's membrane and RPE layer leading to subretinal hemorrhage, fluid accumulation and finally visual impairment in advanced form of AMD. Taken with permission from www.dreamstime.com.