Table 2: Progression trend of AMD from early to advanced level [⁹³-¹⁰⁰].

	Stage of AMD	Number and size of drusen	Other abnormalities	Management
1	Normal aging	No drusen or signs of few small (<63 µm) sized drusen in one/both eyes, or medium sized drusen in one eye	No signs of pigmentation
2	Early AMD	Presence of few medium (63-125 µm) sized drusen in one or both eyes	Pigmentation	Modification of diet and lifestyle
3	Intermediate	Extensive medium drusen in both eyes or at least one large drusen in one eye	Geographical atrophy without macular involvement
4	Advanced dry AMD	Large drusen (>125 µm) drusen or extensive medium in both eyes	Geographical atrophy extending to macula	Lifestyle management, Anti-oxidant supplements
5	Advanced neovascular AMD	Extensive large drusen in the fovea in both eyes besides hemorrhage and scars	CNV, fluid leakage, RPE detachment, Visual acuity less than 20/32	Anti-VEGF therapy, laser therapy