Fig. (1) Schematic representation summarizing the effect of the T-calcium channel blocker Mibefradil on human lens epithelial cells found in our basic in vitro cell culture experiments: a. Membrane potential depolarized, b. Integrin expression reduced, integrins clustered, c. Extracellular matrix proteins clustered, d. Actin cytoskeleton fragmented, vimentin structure altered, e. Opening of the tight junctions − ZO-1 translocation to the cytoplasm, f. Apoptosis − Bax translocation to the mitochondria, g. Apoptosis − phosphatidylser-ine switch, h. Apoptosis − DNA cleavage.