Table 1: Analgesic efficacy of liposome bupivacaine versus bupivacaine HCl in different surgical models at the first postsurgical pain assessment (Unpublished data).

Model/Dose Time Point Liposome Bupivacaine Pain Score, Mean Bupivacaine HCl Pain Score, Mean Treatment Group With Lowest Pain Score* at First Postsurgical Assessment
Inguinal Hernia Repair
LB 155 mg vs. B 100 mg 4h 18 24 LB at 4 hours
LB 199 mg vs. B 100 mg 4h 13 24 LB at 4 hours
LB 266 mg vs. B 100 mg 4h 21 24 LB at 4 hours
LB 310 mg vs. B 100 mg 4h 14 24 LB at 4 hours
LB 93 mg vs. B 105 mg 1h 1.2 1.0 B at 1 hour†
LB 160 mg vs. B 105 mg 1h 0.9 1.0 LB at 1 hour
LB 306 mg vs. B 105 mg 1h 0.7 1.0 LB at 1 hour
Total Knee Arthroplasty
LB 133 mg vs. B 150 mg 24h 3.8 4.3 LB at Day 1
LB 266 mg vs. B 150 mg 24h 3.1 4.3 LB at Day 1
LB 399 mg vs. B 150 mg 24h 3.6 4.3 LB at Day 1
LB 532 mg vs. B 150 mg 24h 2.4 4.3 LB at Day 1
LB 532 mg vs. B 200 mg 2h 3.7 3.2 B at 2 hours‡
Hemorrhoidectomy
LB 66 mg vs. B 75 mg 1h 3.1 2.7 B at 1 hour§
LB 199 mg vs. B 75 mg 1h 1.9 2.7 LB at 1 hour
LB 266 mg vs. B 75 mg 1h 1.6 2.7 LB at 1 hour
LB 266 mg vs. B 100 mg 1h 2.9 2.4 B at 1 hour‖
Breast Augmentation
LB 532 mg vs. B 200 mg 1h 4.1 4.5 LB at 1 hour

B = bupivacaine HCl; LB = liposome bupivacaine.
*An 11-point numeric rating scale at rest (NRS-R) was used to assess pain intensity (PI) in all studies except Study 201, in which a 0- to 100 mm visual analog scale was used.
†Mean PI scores in the liposome bupivacaine group were lower beginning at 12 hours, and remained lower than bupivacaine HCl through 96 hours.
‡Mean PI scores in the liposome bupivacaine group were lower beginning at 60 hours, and remained lower than bupivacaine HCl through 96 hours.
§Mean PI scores in the liposome bupivacaine group were lower beginning at 2 hours, and remained lower than bupivacaine HCl through 96 hours.
‖Mean PI scores in the liposome bupivacaine group were higher than bupivacaine HCl at the 1, 2, and 4 hour assessments; they were lower than bupivacaine HCl at the 8 and 12 hour assessments; then, higher than bupivacaine HCl beginning at 24 hours and remained higher than bupivacaine HCl through 96 hours.