Parameter | Study 1 (inguinal hernia repair) | Study 2 (total knee arthroplasty) | Study 3 (hemorrhoidectomy) | Study 4 (bunionectomy) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
LB 155 mg |
LB 199 mg |
LB 266 mg |
LB 310 mg |
Bupivacaine HCl 100 mg |
LB 133 mg |
LB 266 mg |
LB 399 mg |
LB 532 mg |
Bupivacaine HCl 150 mg |
LB 266 mg |
LB 106 mg |
|
n=12 | n=12 | n=12 | n=14 | n=26 | n=25 | n=24 | n=26 | n=21 | n=30 | n=25 | n=26 | |
Cmax (ng/mL) | 241 (89) |
303 (84) |
365 (130) |
415 (122) |
336 (156) |
262 (277) |
340 (107) |
500 (173) |
935 (371) |
205 (111) |
867 (353) | 166 (93) |
Tmax (h) | 12 (0.5,24) |
10 (0.5,24) |
12 (0.6,48) |
12 (0.2,49) |
0.6 (0.1, 6) |
12 (0.5, 37) |
24 (0.5, 49) |
24 (0.2, 48) |
36 (2, 71) |
24 (0.6, 48) |
0.5 (0.3, 36) | 2 (0.5, 2) |
n=12 | n=12 | n=12 | n=14 | n=26 | n=23 | n=20 | n=21 | n=19 | n=28 | n=24 | n=22 | |
AUC∞ (h•ng/mL) | 9597 (4370) |
10,295 (4486) |
16,758 (6288) |
19,476 (8015) |
4374 (1561) |
7826 (3317) |
17,370 (8540) |
27,630 (12,939) |
60,174 (25,117) |
7460 (4118) |
18,289 (7569) | 7105 (2283) |
t½ (h) | 15.9 (6.7) |
14.1 (5.1) |
14.6 (4.6) |
18.9 (6.2) |
8.5 (2.9) |
13.4 (4.0) |
17.1 (6.8) |
18.8 (5.1) |
16.9 (4.8) |
10.7 (3.9) |
23.8 (39.4) | 34.1 (17.0) |