Fig. (3) Sex Dependent-Osteolysis to CoCr and UHMWPE. A) Normalized to the average bone volume (BV) of sham controls, a comparison of the particle challenged groups with each other revealed a significantly larger amount of osteolysis and osteolysis/bone-volume ratio in the female mice that received CoCrMo particles than in the female mice with UHMWPE particles or particle-treated male mice. B) Normalized to the areal bone (BA) of sham controls, areal measure of osteolysis calculated by histomorphometry of the Hematoxylin Eosin (HE) stained coronal sections of calvaria at the sagittal suture showed that addition of CoCrMo induced >100% more osteolysis in female mice than male mice challenged with CoCrMo or UHMWPE particles (Note: Error Bars indicate standard deviations, and p values of Students T test comparison are as follows: *=p<0.05, **=<0.01, ***=<0.001).