Fig. (1) VEGF transcript isoform changes in endochondral chondrocytes treated with 10 µM (A) or 100 µM (B) alendronate for 24 hours. VEGF n-fold transcription changes for each isoform were calibrated relative to ITS +IGF-I control. Gray bars are ITS+IGF-I control, red bars are alendronate treated cells, green bars are alendronate plus 10µM FOH, and blue bars are alendronate plus 10µM GGOH. All values are expressed as least square means ± SEM. Within an individual VEGF isoform, bars labeled with different letters are significantly different from one another (p < 0.01).