Fig. (3) Heat Sensitivity of AHF Fed Mice on the Modified 44ºC Hotplate Was Attenuated Dose Dependently by Loperamide. (A) At 44ºC AHF fed mice reared significantly more often than control animals while at 38ºC there was no difference. (B) Systemic treatment (i.p.) with loperamide dose dependently attenuated heat responses of AHF fed mice. The 1.2 mg/kg dose significantly reduced heat responses (p<0.05 by two-way repeated measures ANOVA). *p<0.05.