Fig. (1) Effect of intraplantar CFA and CCI on thermal hyperalgesia and mechanical allodynia. A. Intraplantar CFA administration resulted in significant (p<0.05) decrease in PWL at week 1 and lasted for entire duration of study compared to vehicle-treated group. B. Intraplantar CFA administration resulted in significant (p<0.05) decrease in PWT at week 1 after treatment compared to vehicle-treated group thus inducing thermal hyperalgesia and mechanical allodynia. C. CCI resulted in significant (p<0.05) decrease in PWL at week 1 and returned to baseline by week 5 of study compared to vehicle-treated group. D. CCI resulted in significant (p<0.05) decrease in PWT at week 2 and returned to baseline by week 4 of study compared to vehicle-treated group. Asterisks (*) represent p < 0.05 as compared to vehicle-treated or sham-surgery animals.