Table 1: Clinical input parameters.

Parameters Value Distribution LL UL Source
Clinical Input Parameters- Sourced from UK Based Study
Probability of chest infection episodes per month-Pre VestTM system 28.3% Beta 21.26% 35.43% UK-based study
Probability of admissions per patient per month -Pre VestTM system 8.9% Beta 6.71% 11.19% UK-based study
Probability of rate of antibiotic treatments per month-Pre VestTM system 18.0% Beta 13.47% 22.45% UK-based study
Average length of stay in hospital in each admission 11.78 Gamma 5.89 17.67 UK-based study
Probability of chest infection episodes per month-Post VestTM system 3.1% Beta 2.31% 3.85% UK-based study
Probability of admissions per patient per month ->Post VestTM system 4.1% Beta 3.06% 5.10% UK-based study
Probability of rate of antibiotic treatments per month-Post VestTMsystem 16.2% Beta 12.17% 20.29% UK-based study
Average length of stay in hospital in each admission 3.75 Gamma 1.88 5.63 UK-based study
Clinical Input Parameters- Sourced from Yuan et al. 2010
% of participants requiring hospitalization/IV antibiotics at 5 months - MCWP 6.4% Beta 4.84% 8.06% Yuan et al. 2010 [4]
% of participants requiring PO antibiotics at 5 months - MCWP 11.0% Beta 8.26% 13.76% Yuan et al. 2010 [4]
% of participants requiring hospitalization/IV antibiotics at 5 months - HFCWO (The VestTMsystem) 0.0% Beta 0.00% 0.00% Yuan et al. 2010 [4]
% of participants requiring PO antibiotics at 5 months - HFCWO (The VestTM system) 5.3% Beta 3.98% 6.64% Yuan et al. 2010 [4]
Clinical Input Parameters- Sourced from Lechtzin et al. 2016
Risk reduction in inpatient admissions 20.2% Fixed NA NA Lechtzin et al. 2016 [11]
Risk reduction in inpatient bed days 44.8% Fixed NA NA Lechtzin et al. 2016 [11]
Risk reduction inphysician office visits 8.2% Fixed NA NA Lechtzin et al. 2016 [11]
Health Utility
Health utility without respiratory infection 0.40 Beta 0.3 0.5 NG62 [15]
Health utility with respiratory infection 0.21 Beta 0.16 0.27 [16]
Mortality
30 days mortality associated with RTI 45.9 Log Normal 36.8 55.2 [15]
Standardized Mortality Rates (SMR) 8.4 Log Normal 4.20 12.60 [16, 17]