Fig. (3) Effect exerted by both estrone and an amino-steroid-anthracenone derivative (ASA; 0.001-100 nM) against ischemia-reperfusion injury (translated as infarct area). The results showed that ASA significantly (p = 0.05) reduced infarct size expressed as a percentage of the area at risk compared with the estrone. Each data points represents the mean ± S.E. of 9 experiments.