| No | Abbreviated Parameter (unit measurement) | Definition |
|---|---|---|
| PRIMARY OUTCOMES | ||
| 1 | CL/F (l/h) | It is the apparent elimination clearance |
| 2 | Vc/F (l) | It is the apparent volume of distribution of the central compartement |
| 3 | Q1/F (l/h) | These are the inter-compartment clearances between the central and the peripheral compartment |
| 4 | Q2/F (l/h) | |
| 5 | VP1/F (l) | These are the apparent volumes of distribution of the peripheral compartments |
| 6 | VP2/F (l) | |
| 7 | MTT (h) | It is the mean transit time of the absorption |
| 8 | Number of transit compartments | It is the number of transit compartments used in the absorption model |
| 9 | F | It is the relative bioavailability |
| 10 | RUV | It is the variance of the unexplained residual variability |
| COVARIATE RELATIONSHIP | ||
| 11 | Scale | It is the difference between venous and capillary predictions |
| 12 | MF50 (years) | It is the maturation age (years) to reach 50% of the full elimination clearance |
| 13 | HillMF | It is the hill function in the maturation equation, with an upper limit of 10 |
| 14 | DoseF | It represents the increase in relative bioavailability between dosing occasion |
| SECONDARY OUTCOMES | ||
| 15 | Cmax (ng/ml) | It is the maximum concentration |
| 16 | Tmax (h) | It is the time after dose to reach the maximum concentration |
| 17 | T1/2 (d) | It is the terminal elimination half life |
| 18 | AUC∞ (h x ng/ml) | It is the area under the concentration-time curve from time 0 to infinity |
| 19 | Day 7 concentration | It is the venous plasma concentration at day 7 after dosing |
| ADDITIONAL INFORMATION | ||
| 20 | Coefficient of variation for inter-individual variability (IIV) | These are calculated as 100 x (e variance -1)1/2 |
| 21 | Inter-occasion variability (IOV) | |