Table 10: Kinetic models parameters applied to release profiles of Diltiazem Hydrochloride Controlled Release Matrices with Co-excipients (HPMC, CMC-Na and Starch).

Drug-to-Polymer Ratio	W = k1t (Ist-order Kinetics)		(100-w) = ln100-k2t (Zero-order Kinetics)		(100-w)1/3= 1001/3-k3t (Hixon Crowell Model)		W = k4t1/2 (Highuchi Model)		Mt / M∞ = k5 tn (Power Law)
	k1 ± S D	r1	k2 ± SD	r2	k3 ±  SD	r3	k4± SD	r4	k5 ±SD	r5	n
Diltiazem Hydrochloride and Ethocel 45 Premium CR tablets containing HPMC as Co-excipient
10: 1	4.21±0.231	0. 279	0.13±0. 078	0. 581	0. 37±0.078	0.689	5.34±1.109	0.385	0. 01±0 .031	0. 476	0. 061
10:2	5.35±0.298	0.394	0.247±0. 092	0.516	0.441±0.032	0.587	3.651±0.187	0.481	0.11±1.341	0.584	0.073
10:3	3.325±0.123	0.473	0.367±0. 108	0.487	0.623±1.45	0.716	2.981±1.043	0.692	0.278±0.918	0.491	0.089
Diltiazem Hydrochloride and Ethocel 45 Premium CR tablets containing CMC-Na as Co-excipient
10:1	4.354±0. 213	0. 488	0.498±0. 125	0. 314	0. 67±0. 891	0.552	3.34±1.108	0.489	0. 02±0 .451	0. 476	0. 061
10:2	3.43±.098	0.585	0.353±.271	0.376	0.55±0.09	0.663	2.651±0.157	0.585	0.021±2.571	0.684	0.073
10:3	4.5±.143	0.687	0.223±.098	0.483	0.643±.097	0.756	3.981±1.163	0.491	0.078±1.982	0.791	0.089
Diltiazem Hydrochloride and Ethocel 45 Premium CR tablets containing Starch as Co-excipient
10:1	3.123±.09	0.393	0.152±0.287	0.281	0. 672±0. 791	0.499	3.34±2.087	0.565	0. 03±2 .241	0. 375	0. 051
10:2	2.51±.087	0.386	0.286±0.187	0.486	0.352±0.19	0.677	4.651±0.371	0.651	0.21±4.571	0.483	0.033
10:3	4.3±.045	0.291	0.43±.223	0.383	0.476±.097	0.776	2.981±1.432	0.442	0.08±0.582	0.661	0.049