Formulation and In-Vitro Evaluation of Controlled Release Matrix Tablets of Diltiazem Hydrochloride Using Different Rate Controlling Polymers

Table 9: Kinetic models parameters applied to release profiles of Diltiazem Hydrochloride controlled release matrices.

Drug-to-Polymer Ratio	W = k₁t		(100-w) = ln100-k₂t		(100-w)^1/3= 100^1/3-k₃t		W = k₄t^1/2		M_{t /} M_∞ = k₅ tⁿ
Drug-to-Polymer Ratio	k₁ ± S D	r₁	k₂ ± SD	r₂	k₃ ± SD	r₃	k₄± SD	r₄	k₅ ±SD	r₅		n
Diltiazem Hydrochloride and Ethocel 45 Premium CR tablets
10: 1	7.21±0.231	0.679	0.23±0. 178	0. 981	0. 57±0.098	0.889	6.34±1.09	0.985	0. 01±0 .231	0. 976	0. 661
10:2	6.35±0.298	0.894	0.347±0. 392	0.916	0.641±0.132	0.987	4.651±0.87	0.981	0.31±1.541	0.984	0.673
10:3	5.325±0.123	0.873	0.467±0. 198	0.987	0.923±2.45	0.916	3.981±1.43	0.992	0.478±0.98	0.991	0.689
Diltiazem Hydrochloride and K100 LV Methocel
10:1	6.32±0. 213	0.988	0.398±0. 125	0. 214	0. 87±0. 891	0. 952	5.34±1.08	0.989	0. 01±0 .251	0. 976	0. 661
10:2	7.453±.098	0.985	0.453±.271	0.876	0.45±0.09	0.963	7.651±0.57	0.985	0.21±1.571	0.984	0.673
10:3	6±.143	0.987	0.123±.098	0.983	0.543±.097	0.956	4.981±1.63	0.991	0.178±0.982	0.991	0.689
Diltiazem Hydrochloride and K15M EP Methocel Premium CR tablets
10:1	5.123±.09	0.993	0.452±0.087	0.981	0. 872±0. 791	0.899	4.34±1.087	0.965	0. 01±0 .241	0. 975	0. 651
10:2	6.51±.087	0.986	0.786±0.087	0.986	0.452±0.19	0.977	6.651±0.571	0.951	0.11±1.571	0.983	0.633
10:3	7.3±.045	0.991	0.53±.123	0.983	0.576±.097	0.976	5.981±1.632	0.942	0.18±0.982	0.961	0.649