Table 4: Physicochemical response of the formulations in the preliminary study.

Formulation code Weight variation (mg) Hardness (kg/cm2) Thickness (mm) Diameter (mm) Surface
pH
Mucoadhesive time (h)
F1 404.6±2.34 7.0 3.0±0.05 12.0±0.14 5.5 4.0
F2 398.2±2.1 7.2 3.0±0.01 12.0±0.10 6.5 2.5
F3 405.1±3.4 6.4 3.0±0.03 12.1±0.04 6.2 2.5
F4 391.6±1.86 6.1 3.0±0.03 12.3±0.03 6.4 2.0
F5 392.2±5.78 6.3 3.0±0.03 12.0±0.03 5.0 2.0
F6 404.5±3.36 7.3 3.0±0.1 12.0±0.03 5.5 2.0
F7 401.8±3.55 5.5 3.2±0.03 12.0±0.11 6.5 3.0
F8 407.4±1.91 5.6 3.2±0.1 12.3±0.03 7.2 3.0
F9 390.7±4.46 4.1 3.2±0.03 12.3±0.05 6.0 3.0
F10 390.3±3.79 4.7 3.2±0.03 12.0±0.12 7.0 4.0
F11 392.4±4.21 5.2 3.2±0.1 12.1±0.05 7.0 4.0
F12 397.8±4.49 5.2 3.0±0.03 12.0±0.04 6.0 4.0
F13 402.3±4.06 7.4 3.1±0.02 12.0±0.08 6.0 4.0

Thickness and diameter were calculated as mean ± SD of 10 determinants whereas weight variation was performed on 20. (SD = standard deviation).