Fig. (2) Model illustrating the analgesic mechanism of action of the omega-3 PUFA. Key: GPR40 (G-protein-coupled receptor 40), TRPV1 (transient receptor potential vanilloid 1, ASIC (Acid-Sensing Ion Channel), EEQ (epoxyeicosatetraenoic acid) EDP (epoxydocosapentaenoic acid) RvD (resolvin D), RvE (resolvin E), PGE2 (Prostaglandin E2), PLA2 (Phospholipase A2).