Table 1: Characteristics of Studies of Efficacy of omega-3 PUFAs of patients with pain.

Disease	Omega-3 PUFAs (g/day)	Duration of treatment	Study (Ref)
Inflammatory bowel disease	EPA 3.24 g and DHA 2.16 g	4 months	Stenson et al. 1992 [83]
Knee osteoarthritis	fish oil (4.5 g omega-3 fatty acids) 15 ml/day	24 months	Hill et al. 2016 [85]
Rheumatoid arthritis	fish oil (3 g/d)	24 weeks	Berbet et at. 2005 [88]
	15g of MAX-EPA /day (2.7 g of EPA and 1.8 g of DHA/day)	14 weeks	Kremer et al. 1987 [89]
	20 g of Max-EPA/day	6 weeks	Sperling et al. 1987 [92]
	110 (54 EPA and 36 DHA) mg/kg/day	24 weeks	Kremer et al. 1990 [90]
	130 (EPA and DHA) mg/kg /day	8 weeks	Kremer et al. 1995 [91]
	2.04 g EPA and 1.32 g DHA/day	12 weeks	Van Der Temple H et al. 1990 [93]
	3.6 g DHA and EPA/day	12 weeks	Nielsen et al. 1992 [92]
	2.6 g DHA and EPA/day	12 months	Geusens et al 1994 [95]
Neck or back pain - discogenic pain	1.2 g DHA and EPA/day	75 days	Maroon JC et al. (2006) [87]
Neuropathic pain	2.4-7.2 g DHA and EPA/day	19 months	Ko et al. 2010 [97]
Dysmenorrhea	1.08 g EPA and 0.72 g /day	2 months	Harel et al. 1966 [99]
Chronic headaches	1.482 g DHA and EPA/day	12 weeks	Ramsden et al 2015 [84]