Table 1: Distribution of HLA-DRB1 alleles/genotypes among Syrian rheumatoid arthritis patients and healthy controls.

RA Patients
n (%)
Controls
n (%)
Statistical Analyses
Total
(n=81)
ACPA+
(n=51)
ACPA-
(n=30)
(n=40) Patients
vs
controls
ACPA+ pts
vs
controls
ACPA- pts
vs
controls
ACPA+ pts
vs
ACPA- pts
vs
controls
ACPA+ pts
vs
ACPA- pts
ACPA+ GG/TT pts
vs
ACPA- GG/TT pts
HLA-DRB1 alleles
Subjects with R allele(s) 55
(67.9%)
41
(80.4%)
14
(46.7%)
15
(37.5%)
p=.002 (MWW)
τ=.269, p=.003
OR=3.5, p=.002
p=.00 (MWW)
τ=.438, p=.00
OR=6.8, p=.0001
p=.444 (MWW) p=.00 (K-W)
τ=.364, p=.00
p=.002 (MWW)
τ=.349, p=.002
OR=4.7, p=.002
p=.005 (MWW)
τ=.392, p=.005
Subjects with P allele(s) 27
(33.3%)
15
(29.4%)
12
(40%)
30
(75%)
p=.00 (MWW)
τ=.281, p=.002
OR=6, p<.0001
p=.00 (MWW)
τ=.453, p=.00
OR=7.2, p<.0001
p=.003 (MWW)
τ=.354, p=.003
OR=4.5, p=.004
p=.00 (K-W)
τ=.362, p=.00
p=.332 (MWW) p=.793 (MWW)
R alleles frequency 79
(48.7%)
59
(57.8%)
20
(33.3%)
16
(20%)
p=.00 (MWW)
τ=.309, p=.00
p=.00 (MWW)
τ=.474, p=.00
p=.208 (MWW) p=.00 (K-W)
τ=.383, p=.00
p=.007 (MWW)
τ=.286, p=.007
p=.011 (MWW)
τ=.331, p=.011
P alleles frequency 33
(20.4%)
17
(16.7%)
16
(26.7%)
34
(42.5%)
p=.00 (MWW)
τ=.278, p=.002
p=.00 (MWW)
τ=.429, p=.00
p=.023 (MWW)
τ=.264, p=.023
p=.00 (K-W)
τ=.333, p=.00
p=.242 (MWW) p=.667 (MWW)
HLA-DRB1 genotypes
RR 24
(29.6%)
18
(35.3%)
6
(20%)
1
(2.5%)
p=.001 (MWW)
τ=.239, p=.004
p=.00 (MWW)
τ=.350, p=.00
p=.061 (MWW) p=.002 (K-W)
τ=.246, p=.001
p=.644 (MWW) p=.978 (MWW)
RN 21
(25.9%)
15
(29.4%)
6
(20%)
4
(10%)
RP 10
(12.3%)
8
(15.7%)
2
(6.7%)
10
(25%)
NN 9
(11.1%)
3
(5.9%)
6
(20%)
5
(12.5%)
PN 11
(13.6%)
5
(9.8%)
6
(20%)
16
(40%)
PP 6
(7.4%)
2
(3.9%)
4
(13.3%)
4
(10%)

RA, Rheumatoid Arthritis; ACPA, Anti-Citrullinated Protein Antibodies; pts, RA patients; R, Risky HLA-DRB1 allele (DRB1*01, 04, 10); P, protective HLA-DRB1 allele (DRB1*11, 13); N, non-risky, non-protective HLA-DRB1 allele; GG/TT, STAT4 rs7574865 homozygous genotype; MWW, Mann–Whitney U test; K-W, Kruskal-Wallis test; τ, Kendall's tau coefficient; OR, Odds Ratio.

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