Table 2: Distribution of STAT4 rs7574865 alleles/genotypes among Syrian rheumatoid arthritis patients and healthy controls.

RA Patients
n (%)
Controls
n (%)
Statistical Analyses
Total
(n=81)
ACPA+
(n=51)
ACPA-
(n=30)
(n=40) Patients
vs
controls
ACPA+ pts
vs
controls
ACPA- pts
vs
controls
ACPA+ pts
vs
ACPA- pts
vs
controls
ACPA+ pts
vs
ACPA- pts
ACPA+ GG/TT pts
vs
ACPA- GG/TT pts
STAT4 rs7574865 alleles
Subjects with G allele(s) 75
(92.6%)
45
(88.2%)
30
(100%)
36
(90%)
p=.628 (MWW) p=.790 (MWW) p=.077 (MWW) p=.161 (K-W) p=.052 (MWW) p=.045 (MWW)
τ=.278, p=.045
Subjects with T allele(s) 35
(43.2%)
25
(49%)
10
(33.3%)
15
(37.5%)
p=.550 (MWW) p=.274 (MWW) p=.721 (MWW) p=.323 (K-W) p=.171 (MWW) p=.029 (MWW)
τ=.304, p=.029
G allele frequency 121
(74.7%)
71
(69.6%)
50
(83.3%)
61
(76.3%)
p=.670 (MWW) p=.311 (MWW) p=.525 (MWW) p=.233 (K-W) p=.095 (MWW) p=.029 (MWW)
τ=.301, p=.029
T allele frequency 41
(25.3%)
31
(30.4%)
10
(16.7%)
19
(23.8%)
p=.670 (MWW) p=.311 (MWW) p=.525 (MWW) p=.233 (K-W) p=.095 (MWW) p=.029 (MWW)
τ=.301, p=.029
STAT4 rs7574865 genotypes
GG 46
(56.8%)
26
(51%)
20
(66.7%)
25
(62.5%)
p=.754 (MWW) p=.392 (MWW) p=.525 (MWW) p=.310 (K-W) p=.131 (MWW) p=.045 (MWW)
τ=.278, p=.045
GT 29
(35.8%)
19
(37.3%)
10
(33.3%)
11
(27.5%)
TT 6
(7.4%)
6
(11.8%)
0
(0%)
4
(10%)

RA, Rheumatoid Arthritis; ACPA, Anti-citrullinated Protein Antibodies; pts, RA patients; STAT4, signal transducer and activator of transcription 4 gene; MWW, Mann–Whitney U test; K-W, Kruskal-Wallis test; τ, Kendall's tau coefficient.

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