High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis

Table 3: Cytokines levels secreted by unstimulated and TDB (5µg/ml) stimulated PBMCs of patients with TA and healthy controls.

*ELISA (pg/ml)*	*Unstimulated Control* *Median (range)*	*TDB Stimulated PBMC Supernatant Levels (5µg/ml)*	*p Value*
IL-6_HC	789(77.73-1834)	2052(452.2-4067)	< 0.0001
IL-6_TA	158(41-1948)	2313(554.5-7368)	0.0007
TNF-α_HC	20(7.5-33.5)	67(25-103)	< 0.0001
TNF-α_TA	15(7.25-36.5)	52.5(31.25-102)	0.0037

HC – healthy control, TA – Takayasu arteritis