High Secretion of Interleukin-6 and Increased MINCLE Receptor Expression Upon Exposure to Mycobacterial Cord Factor Analog Trehalose-6, 6-Dibehenate (TDB) in Patients with Takayasu Arteritis

Table 4: Cytokines levels secreted by unstimulated and TDB (50µg/ml) stimulated PBMCs of patients with TA and healthy controls.

*ELISA (pg/ml)*	*Unstimulated Control* *Median (range)*	*TDB Stimulated PBMC Supernatant Levels (50µg/ml)*	*p Value*
IL-6 HC	1236(246-1836)	2192(613.2-3492)	0.0057
IL-6 TA	129.4(50.51-1100)	5096(996.8-15061)	0.0012
TNF-α HC	23.5(10.25-42.25)	268(35-563)	0.0010
TNF-α TA	12.5(7.25-22.75)	205(33.25-463.3)	0.0017