Table 2: The table summarizes the principle evidences of the role of vitamin D in RA related osteoporosis.

Author Year [Cit. Number] Main Findings
Zhang J, et al. 2012 [102] Vitamin D decreases production of IL-6 and TNFα
Ranganathan P, et al. 2009 [103] Specific Vitamin D Receptor (VDR) alleles are associated with accelerated generalized bone loss in RA
Rass P, et al. 2006 [104] The B allele of the VDR gene BsmI polymorphism is correlated with increased osteoclast and osteoblast function
Sainaghi PP, et al. 2011 [105] Presence of higher plasma PTH levels, contributing to the development of a “relative hyperparathyroidism” condition
Sainaghi PP, et al. 2013 [112] High loading dose of cholecalciferol (300.000 UI), followed by a maintenance daily dose(600-800 UI), could be more effective in inducing PTH suppression

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