Table 1: Demographic characteristics of patients under 4 years of age who received ETA and ADA.

Parameter ADA (no Uveitis) (n=12) ADA (Uveitis) (n=13) ETA (no Uveitis) (n=49) P between ADA (no Uveitis) and ADA (Uveitis) P between ADA (no Uveitis) and ETA (no Uveitis) P between ADA (Uveitis) and ETA (no Uveitis)
Females, n (%) 6 (50%) 8 (61.54%) 41 (83.67%) 0.859 0.035 0.174
Active uveitis at the start of treatment, n (%) 0 (0%) 13 (100%) 0 (0%) <0.001 <0.001
Diagnosis
extended oligoarthritis, n (%) 0 (0%) 2 (15.38%) 7 (14.29%) 0.706 0.011 0.225
persistent oligoarthritis, n (%) 5 (41.67%) 6 (46.15%) 32 (65.31%)
RF- polyarthritis, n (%) 5 (41.67%) 4 (30.77%) 10 (20.41%)
psoriatic arthritis, n (%) 2 (16.67%) 1 (7.69%) 0 (0%)
Age at disease onset, median (IQR), years 2.25 (1.38: 3.08) 2 (1.5: 2.9) 1.8 (1.4: 2.2) 0,7 0,283 0.258
Age at start of current therapy (ETA/ADA), median (IQR), years 3.9 (3.1: 4) 3.7 (3.4: 3.9) 2.8 (2: 3) 0.56 <0.001 0.003
JIA duration before start ETA/ADA, median
(IQR), years
1 (0.57: 1.7) 1.1 (0.9: 2) 0.6 (0.4: 1) 0.682 0.054 0.012
Prior therapy with biologics, n (%) 4 (33.3%) 4 (30.8%) 2 (4.1%) >0.999 0.011 0.015
Prior therapy with methotrexate, n (%) 11 (91.7%) 13 (100%) 31 (63.3%) >0.999 0.083 0.013

ETA – Etanercept, ADA – adalimumab, IQR – interquartile range.