Table 4: Risk factors associated with low BMD in the IBD patients.

Risk Factors Low BMD Normal BMD Control Group p
Gender:
Male: N (%)
Female: N (%)
13 (32. 5)
15 (37. 5)
4 (10)
8 (20)
15(47)
17(53)
NS §
Age (years)* 46.42 ± 14.33 39.75 ± 10.42 44,72 ± 14,12 NS
BMI (kg/m2)* 20.71 ± 3.06 21.52 ± 4.59 25.05± 3,96 0.001
Type of IBD:
CD: N (%)
UC: N (%)
14 (35)
14 (35)
5 (12.5)
7 (17.5)
NS §
IBD duration (months)* 58.41 ± 86.23 45.92 ± 54.75 NS ¥
Corticosteroids:
Yes: N (%)
No: N (%)
16 (40)
12 (30)
6 (15)
6 (15)
0
0
NS §
Cumulative dose of steroids (mg)** 515 (0 – 11200) 250 (0– 23900) 0 NS ¥
Bowel surgery:
Yes: N (%)
No: N (%)
2 (5)
24 (60)
4 (10)
10 (25)
0
0
NS §
Disease localization (CD): Colonic: N (%)
Ileocolonic + ileal: N (%)
2 (10.5)
12 (63.2)
0
5 (26.3)
NS §
Disease localization (UC): Proctitis: N (%)
Left side colitis+pancolitis: N (%)
3 (14.3)
11 (52.4)
2 (9.5)
5 (23.8)
NS §
ESR* 49 ± 15.67 31.8 ± 13.1 10 0.039
Calcium (mmol/l)* 2.43 ±0.11 2.42 ±0.16 2,42 ± 0,10 NS
Phosphorus (mmol/l)* 1.22 ±0.19 1.23 ±0.25 1,13 ± 0,20 NS
Alcaline phosphatase (UI/L)* 108.12 ±45.26 89.8 ±41 88,75 ± 44,18 NS
25-OH vitamin D (ng/ml)** 3,65 3 9.03 0.009 ¥
PTH (pg/ml) ** 42.11 55.4 41.57 NS ¥
Serum osteocalcin (ng/ml) ** 28.74 18.51 24.6 NS ¥
Urinairy CTX (µg/ mmol urinary creatinine)** 541.58 358.15 343.3 NS ¥
Fractures (%) 0 0 0 NS §

* Mean value; **Median value; ¶ Student t- Test; ¥ U- Mann-Whitney test; § Chi-squared test. N: number; BMD: Bone Mineral Density; BMI: Body Mass Index; IBD: inflammatory bowel disease; CD: Crohn’s Disease; UC: Ulcerative Colitis; ESR: Erythrocyte Sedimentation Rate; PTH: parathyroid hormone; CTX: Cross Laps; NS: not significant