Table 2: Baseline disease characteristics of patients with AS and PsA.
| Characteristics |
AS (N = 187)
|
PsA (N = 385)
|
P-value |
Total (N = 572)
|
| Disease activity at baseline, mean (SD) |
– |
– |
– |
– |
| PhGA, score 0-10 |
5.9 (1.8) |
5.5 (2.1) |
0.051°°° |
5.6 (2.0) |
| BASDAI, score 0-10 |
5.5 (1.9) |
NA |
0.384°°° |
5.5 (1.9) |
| PASI, score |
NA |
8.8 (12.4) |
NA |
8.8 (12.4) |
| Tender joints (68 joints) |
NA |
7.9 (8.1) |
NA |
7.9 (8.1) |
| Swollen joints (66 joints) |
NA |
4.1 (5.5) |
NA |
4.1 (5.5) |
| BDI-II, 0–63 |
12.7 (9.2) |
11.5 (9.2) |
0.127°°° |
11.9 (9.2) |
| PsAID-12, 0–10 |
NA |
5.0 (2.2) |
NA |
5.0 (2.2) |
| ASAS-HI, 0–17 |
8.4 (3.7) |
NA |
NA |
8.4 (3.7) |
| CRP (mg/L), median |
7.6 |
4.6 |
0.003°°° |
5.5 |
| CRP (mg/L) IQR (Q1-Q3) |
3.0-22.0 |
2.2-11.8 |
NA |
2.4-13.5 |
| CRP >5.0 mg/L, n (%) |
94 (50.3) |
148 (38.4) |
0.004° |
242 (42.3) |
| Comorbidities at baseline, n (%) |
|
Coronary heart disease
|
5 (2.7) |
32 (8.3) |
0.065°° |
37 (6.5) |
|
Stroke
|
0 |
8 (2.1) |
0.134°° |
8 (1.4) |
|
Heart failure
|
1 (0.5) |
12 (3.1) |
0.202°° |
13 (2.3) |
|
Plaque psoriasis†
|
| Mild |
11 (5.9) |
81 (21.1) |
NA |
92 (16.1) |
| Moderate |
6 (3.2) |
111 (28.9) |
NA |
117 (20.5) |
| Severe |
1 (0.5) |
48 (12.5) |
NA |
49 (8.6) |
|
Uveitis
|
9 (4.8) |
3 (0.8) |
0.005°° |
12 (2.1) |
|
Depression*
|
17 (9.1) |
60 (15.6) |
0.021°° |
77 (13.5) |
*Only in case of diagnosis by physician/reported in patient health record.
†
Missing values not included in the % calculation for PsA subgroup.
ACR, American College of Rheumatology; AS, ankylosing spondylitis; ASAS-HI, Assessment of SpondyloArthritis international Society Health Index; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BDI-II, Beck Depression Inventory; CHD, Coronary heart disease; CRP, C-Reactive Protein; IQR, interquartile range; N, number of patients; NA, Not Applicable/Not Available; PASI, Psoriasis Area and Severity Index; PhGA, Physician’s Global Assessment; PsA, psoriatic arthritis; PsAID-12, Psoriasis Arthritis Impact of Disease (12-item); SD, standard deviation.
°Fisher´s exact test, °°Chi-square test, °°°Wilcoxon test