Table 3: Prior therapies in patients with AS and PsA.

Prior therapies, n (%) AS
(N = 187)
PsA
(N = 385)
P-value
(Chi-square test)
Total
(N = 572)
NSAIDs 112 (59.9) 96 (24.9) <.0001 208 (36.4)
Other analgesics 32 (17.1) 31 (8.1) 0.0012 63 (11.0)
DMARDs 70 (37.4) 280 (72.7) 350 (61.2)
  Methotrexate * 40 (21.4) 219 (56.9) <.0001 259 (45.3)
  Azathioprin * 1 (0.5) 4 (1.0) 0.5434 5 (0.9)
  Sulfasalazin * 50 (26.7) 66 (17.1) 0.0074 116 (20.3)
  Leflunomid * 11 (5.9) 110 (28.6) <.0001 121 (21.2)
  Cyclosporine * 0 42 (10.9) <.0001 42 (7.3)
  Chloroquin/hydrochloroquin * 2 (1.1) 7 (1.8) 0.4997 9 (1.6)
  Gold compound * 2 (1.1) 4 (1.0) 0.9732 6 (1.0)
Secukinumab #* 37 (19.8) 91 (23.6) NA 128 (22.4)
Other biologics 120 (64.2) 260 (67.5) 380 (66.4)
  Adalimumab * 81 (43.3) 164 (42.6) 0.8707 245 (42.8)
  Etanercept * 73 (39.0) 121 (31.4) 0.0714 194 (33.9)
  Infliximab * 41 (21.9) 42 (10.9) 0.0004 83 (14.5)
  Certolizumab pegol * 38 (20.3) 40 (10.4) 0.0012 78 (13.6)
  Golimumab * 54 (28.9) 65 (16.9) 0.0009 119 (20.8)
  Ustekinumab * 1 (0.5) 82 (21.3) <.0001 83 (14.5)
Biosimilars 2 (1.1) 5 (1.3) 7 (1.2)
      Infliximab 1 (0.5) 5 (1.3) 0.7421 6 (1.0)
      Etanercept 1 (0.5) 0 0.1510 1 (0.2)
Others 24 (12.8) 73 (19.0) 97 (17.0)
      Apremilast 0 24 (6.2) 0.0005 24 (4.2)

#Start of secukinumab therapy prior to BSL.
*Many patients were exposed to more than one DMARD/biologic.
AS, ankylosing spondylitis; DMARDs, Disease-Modifying Anti-Rheumatic Drugs; NA, Not Applicable/Not Available; NSAIDs, Non-Steroidal Anti-Inflammatory Drugs; PsA, psoriatic arthritis.