Fig. (3) IGFBP-5 expression increases dermal thickness. Human skin explants were injected with control Ad (cAd), Ad expressing IGFBP-3 (Ad3) or Ad expressing IGFBP-5 (Ad5). Dermal thickness was assessed one week post-injection. (A) Expression of IGFBP-5 and to a lesser extent IGFBP-3 results in increased dermal thickness. H&E, 40x. (B) Graphical presentation of dermal thickness. *p < 0.02; **p < 0.04. Data represent four independent experiments using human skin explants from four donors.