Fig. (5) IGFBP-5 and IGFBP-3 expression increases collagen bundle thickness. Human skin explants were treated as in figure 3. The thickness of individual collagen bundles was measured. (A) IGFBP-3 and IGFBP-5 expression results in increased thickness of individual collagen bundles. (B) Graphical presentation of data presented in A. *p < 0.02. Data represent four independent experiments using skin explants from four different donors. H & E, 800X.