Table 2: Significant Changes in Markers Expressed in Various ANKH-Transfectants Relative to that of the neo-Controls at Each Time-Point

Transfectant ITS Sox9 Sox5 Sox6 Col2α1 ColX BSP MMP-13 ALP Activity TNAP Protein
ANKH-wt D0 ↑1.4x ↑7.9x ↓5x ↑7.7x
D10 ↓1.7x ↓2x ↓33x ↓10x ↓2.5x
D17 ↓33x ↓2.5x ↓3.3x
D23 ↑1.6x ↓2x ↓10x ↓33x ↓2.5x ↓4x ↓2x
ANKH- ΔE490 D0 ↓3.3x
D10 ↓50x ↓10x ↓2.5x ↓3.3x ↓2.8x
D17 ↑9.6x ↑1.9x ↑4.6x ↓3.3x ↓5x ↓2x
D23 ↑2x ↑2.6x ↑3.3x ↑2.5x ↓10x ↓2.5x ↓6x ↓2x