Table 1: Cases With Primary SS and Lymphoma Treated with Rituximab

Author, Years N. of Pts Type of Lymphoma/Bone Marrow Involvement Ann Arbor Stage Response Other Concomitantly Immunosuppressive Agents
  Somer, 2003   1   Parotid gland MALT-type/no IE Yes   No
  Voulgarelis, 2004*   4
  1. Salivary gland MALT-type/yes*
  2. Nodal marginal zone/no*
  3. Pulmonary MALT-type/yes*
  4. Salivary gland MALT-type/yes*
IV
IIE
IV
IV		 Yes
Yes
Yes
Yes
  1. CHOP
  2. CHOP
  3. CHOP
  4. CHOP
  Harner, 2004   1   Nodal marginal zone/Pulmonary MALT-type/no IIE Yes   No
  Ramos-Casals, 2004   2
  1. Ovarian MALT-type/yes
  2. Ocular MALT-type/yes
 IV
IV		 Yes
Yes
  1. CHOP
  2. Local radiotherapy
  Pijpe, 2005   1   Parotid gland MALT-type/no IE Yes   No
  Gottenberg, 2005#   2
  1. Digestive tract MALT-type/no#
  2. Salivary gland MALT-type/no#
IE
IE		 Yes
No
  1. MP 500 mg x 4, HQ
  2. No
  Pijpe, 2005   7
  1. Parotid gland MALT-type/no
  2. Parotid gland MALT-type/no
  3. Parotid gland MALT-type/no
  4. Parotid gland MALT-type/no
  5. Parotid gland MALT-type/no
  6. Parotid gland MALT-type/no
 IE
IE
IE
IE
IE
IE
IE		 No
No
Yes
Yes
No
Yes
No
  1. No
  2. PDN 15 mg/day
  3. No
  4. No
  5. PDN 7.5 mg/day, MTX
  6. PDN 5 mg/day, AZA
  7. No
  Voulgarelis, 2006*   6
  1. Nodal marginal zone/no
  2. DLBCL/no
  3. Salivary gland MALT-type/yes
  4. *Nodal marginal zone/no*
  5. Pulmonary MALT-type/yes*
  6. Salivary gland MALT-type/yes*
II
II
IV
IIE
IV
IV		 Yes
Yes
Yes
Yes
Yes
Yes
  1. CHOP
  2. CHOP
  3. CHOP
  4. CHOP
  5. CHOP
  6. CHOP
  Seror, 2007#   5
  1. Salivary gland MALT-type/no#
  2. Nodal marginal zone/yes
  3. Gastric/pulmonary MALT-type/no
  4. Gastric MALT-type/no#
  5. DLBCL/no
 IE
IV
IV
IE
III		 No
Yes
Yes
Yes
Yes
  1. No
  2. No
  3. Mini-CHOP
  4. HQ
  5. CHOP
  Present report   1   Parotid gland MALT-type/no IE No   High-dose steroids

* There is some patients’ overlapping between the cases reported in Voulgarelis, 2004 and Voulgarelis, 2006.
# There is some patients’ overlapping between the cases reported in Gottenberg, 2005 and Seror, 2007.
Abbreviations: pts, patients; MALT, mucosa-associated lymphoid tissue; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; AZA, azathioprine; PDN, prednisone;MTX, methotrexate; MP, methylprednisolone; DLBCL, diffuse large B-cell lymphoma; HQ, hydroxychloroquine.