Study 1 | Study 2 | |||
---|---|---|---|---|
All Patients N = 240,568 |
New Users N =144,059 |
All Patients N = 213,802 |
New Users N =132,381 |
|
OR (95% CI) | ||||
Female Age at index date |
0.62 (0.62, 0.63) 0.92 (0.92, 0.92) |
0.75 (0.73, 0.76) 0.91 (0.91, 0.91) |
0.59 (0.58, 0.60) 0.91 (0.91, 0.91) |
0.68 (0.66, 0.69) 0.90 (0.90, 0.90) |
NSAIDs in prior year | 5.70 (5.63, 5.78) | 14.72 (14.48, 14.96) | ||
GI test in prior year Peptic ulcer disease GPA in prior year PPI H2RA Misoprostol GPA at index date PPI H2RA Misoprostol |
0.76 (0.74, 0.78) 0.81 (0.77, 0.85) 0.52 (0.51, 0.53) 0.58 (0.57, 0.60) 0.77 (0.75, 0.80) 1.52 (1.48, 1.56) 1.14 (1.10, 1.18) 9.82 (9.28, 10.38) |
0.74 (0.70, 0.77) 0.73 (0.66, 0.80) 0.56 (0.54, 0.58) 0.70 (0.67, 0.73) 0.56 (0.44, 0.72) 1.60 (1.53, 1.68) 0.94 (0.87, 1.01) 12.55 (11.21, 14.05) |
0.70 (0.67, 0.72) 0.70 (0.65, 0.76) 0.52 (0.51, 0.53) 0.56 (0.54, 0.58) 0.79 (0.72, 0.87) 1.55 (1.51, 1.59) 0.96 (0.90, 1.02) 12.80 (10.96, 14.96) |
0.70 (0.66, 0.74) 0.54 (0.47, 0.62) 0.62 (0.60, 0.64) 0.73 (0.68, 0.79) 0.86 (0.58, 1.29) 1.79 (1.72, 1.86) 0.99 (0.86, 1.13) 15.52 (10.87, 22.15) |
Comorbidities Anemia/blood disease Renal failure COPD Osteoarthritis Rheumatoid arthritis |
0.77 (0.75, 0.80) 0.58 (0.55, 0.62) 0.65 (0.63, 0.66) 0.73 (0.72, 0.74) 1.74 (1.69, 1.79) |
0.75 (0.71, 0.78) 0.49 (0.44, 0.54) 0.68 (0.65, 0.71) 1.33 (1.33, 1.37) 1.41 (1.30, 1.54) |
0.78 (0.75, 0.80) 0.43 (0.40, 0.47) 0.67 (0.65, 0.70) 0.72 (0.71, 0.74) 1.80 (1.73, 1.87) |
0.74 (0.70, 0.79) 0.51 (0.46, 0.57) 0.63 (0.59, 0.66) 1.07 (1.03, 1.11) 1.45 (1.30, 1.61) |
Prior CV risk factors CHF IHD Acute CVD PVD |
0.90 (0.88, 0.93) 0.96 (0.94, 0.98) 0.73 (0.70, 0.77) 0.76 (0.74, 0.79) |
0.68 (0.64, 0.73) 0.86 (0.83, 0.89) 0.51 (0.47, 0.55) 0.70 (0.66, 0.75) |
0.86 (0.82, 0.90) 0.92 (0.90, 0.94) 0.55 (0.52, 0.59) 0.74 (0.70, 0.77) |
0.81 (0.75, 0.87) 0.91 (0.87, 0.94) 0.38 (0.35, 0.42) 0.66 (0.62, 0.71) |
Prior*medication use Antidiabetic Antihypertensive Lipid lowering agents SSRI Vasodilator Medication use in prior 90 days Anticoagulant Corticosteroid Clopidogrel Aspirin |
0.69 (0.68, 0.70) 0.77 (0.76, 0.78) 0.93 (0.91, 0.94) 0.55 (0.53, 0.56) 0.77 (0.76, 0.79) 0.31 (0.30, 0.32) 0.84 (0.82, 0.86) 0.86 (0.72, 1.02) 0.71 (0.70, 0.72) |
0.66 (0.64, 0.69) 0.88 (0.86, 0.90) 1.10 (1.07, 1.13) 0.57 (0.54, 0.60) 1.00 (0.97, 1.04) 0.29 (0.27, 0.30) 0.84 (0.80, 0.88) 0.47 (0.39, 0.56) 0.72 (0.70, 0.74) |
0.64 (0.64, 0.66) 0.74 (0.73, 0.76) 0.95 (0.93, 0.93) 0.49 (0.47, 0.51) 0.77 (0.75, 0.79) 0.34 (0.32, 0.35) 0.90 (0.87, 0.93) 0.57 (0.54, 0.61) 0.69 (0.68, 0.71) |
0.66 (0.63, 0.68) 0.85 (0.83, 0.87) 1.02 (0.98, 1.05) 0.49 (0.46, 0.52) 0.94 (0.90, 0.98) 0.25 (0.23, 0.26) 0.85 (0.80, 0.90) 0.47 (0.43, 0.51) 0.71 (0.69, 0.73) |