The Frequency of A1298C and C677T Polymorphisms of the Methylentetrahydrofolate Gene in Turkish Patients with Rheumatoid Arthritis: Relationship with Methotrexate Toxicity

Table 7: The Distribution of Disease Activity Parameters According to MTHFR A1298C Polimorphism in RA Patients

	AA (n=24)	AC (n=31)	CC (n=9)	p^a
HAQ (median)	0.5 (0-2.5)^b	1.1 (0-3)^b,^c	0.25 (0-1.6)^c	0.005
DAS28 (median)	4.1 (2.4-6.9)	4.3 (1.7-7.8)	3.4 (2.6-5.8)	0.347
Larsen Score (median)	2.0 (1.0-5.0)	3.0 (1.0-5.0)	2.0 (1.0-5.0)	0.220
ESR (median)	26.5 (6.0-120.0)	36.0 (2.0-110.0)	29.0 (3.0-50.0)	0.344
CRP (median)	0.7 (0.2-10.0)	0.8 (0.1-10.5)	0.5 (0.2-2.5)	0.386

^a Analysis of variance among the genotypes

^b Statistically significant difference between AA and AC (p=0,003).

^c Statistically significant difference between AC and CC (p=0,002).

HAQ: The Health Assessment Questionnaire, DAS 28: Disease Activity Score, ESR: Sedimentation, CRP: C- reactive protein, MTX: Methotrexate, DMARD: Disease-modifying antirheumatic drugs, NSAII: Nonsteroidal anti-inflammatory drugs.