Fig. (4) Fibrosis is associated with lipoatrophy. Skin biopsies demonstrating the association of dermal fibrosis with loss of the subjacent
adipose tissue (adipose atrophy). A. SSc skin biopsy. Note dense dermal fibrosis and loss of subcutaneous fat. *, invasion of fibrotic tissue in
adipose tissue. H&E stain, original magnification x 25. B. Skin biopsy from mouse with bleomycin-induced scleroderma. Note dense dermal
fibrosis and absence of subcutaneous fat. Masson’s trichrome staining, original magnification x 100 (upper panel), 400 (lower panel).