| Ligands of PPAR-γ Inhibit ECM Gene Expression and/or Myofibroblast Transformation in Cultured Cells | Ligands of PPAR-γ Attenuate Fibrosis in Rodent Models |
|---|---|
| Hepatic stellate cells | Choline-deficient, l-amino acid-defined (CDAA) diet induced hepatic fibrosis |
| Hepatocytes | Methionine choline deficient (MCD) diet-induced fibrosing steatohepatitis |
| Hepatoma cells | Thioacetamide-induced hepatic fibrosis |
| Schistosoma japonicum induced hepatic fibrosis | |
| Renal mesagial cells | Fischer to Lewis rat renal transplantation induced chronic renal allograft damage |
| Glomerular endothelial cells | Renal injury in DOCA-salt hypertensive rats |
| Kidney fibroblasts | Diabetes associated glomerulosclerosis, tubulointerstitial fibrosis |
| BDL induced hepatic fibrosis | |
| Lung fibroblasts | Bleomycin-induced pulmonary fibrosis |
| Alveolar epithelial cells | Hypoxia induced pulmonary hypertension |
| Cardiac fibroblasts | Pressure-overload-induced cardiac remodeling |
| Cardiovascular smooth muscle cells | Cardiac fibrosis in Type 2 diabetic rat |
| Normal and Skin fibroblasts; SSc | Bleomycin induced skin fibrosis |