Fig. (2) The Caveolin-1/CXCR4/CXCL12 Axis in Fibrosis.
Profibrotic signals induce the differentiation in the bone marrow of
a population of CD45+/CXCR4+/ColI+/caveolin-1 low cells that
can be either CD14+ (filled circles) or CD14- (open circles). Under
the influence of CXCL12, these cells traffic into the blood, then
into damaged lung tissue where they begin to lose CD45 and to
differentiate into myofibroblasts. CD45+/CXCR4+/ColI+/CD14-
cells are fibrocytes, CD45+/CXCR4+/ColI+/CD14+ cells are
referred to as collagen-producing monocytes [70].