Symptom-Modifying Effect of Chondroitin Sulfate in Knee Osteoarthritis: A Meta-Analysis of Randomized Placebo-Controlled Trials Performed with Structum®

Table 2: Characteristics of Identified Randomised Placebo-Controlled Trials of Chondroitin Sulfate (Structum^®) in Osteoarthritis of the Knee

Study	Treatment (Daily Dose)	Treatment Duration (Months)	Concealment Adequate	Patient Blinding Adequate	ITT Performed	Patients Randomized (Structum^®/Placebo)	Mean Age	% Women	Joint Affected	Outcomes extracted	Funding Source	Jadad Score
Knüsel et al. 2000 [²¹]	Chondroitin sulfate 1g/day (Structum^®)	6	yes	yes	yes	145 (72/73)	61	70	knee	-VAS (pain) -algo-functional index (AFI) -OMERACT-OARSI responder	Laboratoires Pierre Fabre	5
Mazières et al. 2001 [⁸]	Chondroitin sulfate 1g/day (Structum^®)	3	yes	yes	yes	132 (64/68)	67	74	knee	-VAS (pain) -algo-functional index (AFI) -OMERAC -OARSI responder	Laboratoires Pierre Fabre	5
Mazières et al. 2007 [⁹]	Chondroitin sulfate 1g/day (Structum^®)	6	yes	yes	yes	311 (155/156)	67	70	knee	-VAS (pain) -algo-functional index (AFI) -OMERACT-OARSI responder	Laboratoires Pierre Fabre	5