Table 1: Catalytic and Regulatory Subunits of PI3Ks and their Lipid Substrates and Products

Catalytic Subunit Regulatory Subunits Substrate Product
Class 1A p110α
p110β
p110δ
p85α, p85β, p55α, p55γ, p50α PI-4,5-P2 PIP3
Class 1B p110γ p101, p84 PI-4,5-P2 PIP3
Class II PIK3-C2α
PIK3-C2β
PIK3-C2γ
PI-4-P
PI
PI-3,4-P2
PI-3-P
Class III VPS34 p150 PI PI-3-P

Note that while there are three different types of PIP2 (PI-3,4-P2, PI-3,5-P2 and PI-4,5-P2), there is only one kind of PIP3 headgroup (PI-3,4,5-P3),