Table 2: Selected Mouse Models of PI3K p110γ and p110δ Signalling and their Principle Phenotypic Findings (Also Reviewed in [⁹⁰-⁹²]). p110δ^D910A Mice Harbour a Point Mutation Rendering the Kinase Inactive

Model	Details	Cells /Conditions Studied
PI3Kγ-/- [42-44]	PI3Kγ knock-out	T cells [43,47-50]
		NK cells [24, 51-53]
		Neutrophils [42-4, 54-57]
		Mast cells [58]
		Dendritic cells [59]
PI3Kγcx/cx [60]	Constitutively active PI3Kγ	Neutrophils and macrophages.
PI3KγKD/KD [12]	Kinase-inactive PI3Kγ	Neutrophils and macrophages.
PI3Kδ-/- [45, 46]	PI3Kδ knock-out	B cells [45, 46, 61-63]
		T cells [45, 64]
		NK cells [51, 53, 65]
PI3Kδ selective inhibitors [66]	IC87114	B cells [67-69]
		Neutrophils [56, 66, 70]
		T cells [71-73]
PI3KδD910A/D910A [41]	Kinase-dead PI3Kδ	B cells [41, 67, 68, 74, 75]
		T cells [41, 48, 72, 76-81]
		Mast cells [82, 83]
		Neutrophils [26, 56]
		Dendritic cells [81, 84]
		NK cells [24, 52]
PI3KγKO/δD910A [85] OR PI3Kγ-/-δ-/- [86, 87]	PI3Kγ knock-out, PI3Kδ kinase-inactive; PI3Kγ and PI3Kδ knock-out..	T cells [85-88]
		B cells [89]
		NK cells [51]