The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases

Table 3: Murine Models of PI3K Activity in RA

Model	Details	Isoforms Studied
CIA	Markedly reduced joint inflammation	Pharmacological p110γ or pan-PI3K inhibition [¹⁴⁴, ¹⁴⁶]
αCII-IA	Markedly reduced joint inflammation, reduced neutrophil invasion	Pharmacological and genetic p110γ inhibition [¹⁴⁴]
Antigen-induced arthritis	Reduced joint inflammation, reduced activation and migration of phagocytes	Pharmacological and genetic p110γ inhibition[¹⁴⁷]
K/BxN	Reduced joint inflammation, particularly in dual p110γ / p110δ inhibited mice, reduced LTB₄ induced neutrophil accumulation	p110γ^-/- p110δ^-/- p110δ pharmacological inhibition Combined p110γ^-/-p110δ^-/-[¹¹⁹]