Model | Details | Isoforms Studied |
---|---|---|
CIA | Markedly reduced joint inflammation | Pharmacological p110γ or pan-PI3K inhibition [144, 146] |
αCII-IA | Markedly reduced joint inflammation, reduced neutrophil invasion | Pharmacological and genetic p110γ inhibition [144] |
Antigen-induced arthritis | Reduced joint inflammation, reduced activation and migration of phagocytes | Pharmacological and genetic p110γ inhibition[147] |
K/BxN | Reduced joint inflammation, particularly in dual p110γ / p110δ inhibited mice, reduced LTB4 induced neutrophil accumulation | p110γ-/- p110δ-/- p110δ pharmacological inhibition Combined p110γ-/-p110δ-/-[119] |