| Model | Details | Isoforms Studied |
|---|---|---|
| Class 1A PI3K induced SLE (p65 regulatory subunit renders class 1A PI3K constitutively active, inducing SLE) | Prolonged lifespan, reduced CD4 cell survival, autoantibodies and glomerulonephritis | Genetic and pharmacological inhibition of p110γ(169) |
| MRLlpr | Prolonged lifespan and reduced glomerulonephritis, reduced lymphoid cells and autoantibodies | Pharmacological inhibition of p110γ(168) |