Table 5: Other Autoimmune and Inflammatory Conditions with Preclinical Evidence for PI3K Inhibition as a Potential Treatment

Model	Isoforms Investigated and References
Passive cutaneous anaphylaxis	p110δ [82, 83], p110γ [58]
Asthma/airway inflammation	p110δ [78, 147, 175-178], p110γ [127, 179], dual p110δ and p110γ inhibition [180]
Experimental autoimmune encephalitis	p110δ [102] and p110γ [109, 122]
Atherosclerosis	p110γ [181]
Contact and delayed type hypersensitivity	p110δ [71], p110γ [59]