Table 1: Overview of Study Design, Baseline Characteristics and Scales Used to Measure Pain and Physical Functioning

Length of Double Blind TX Period Joints Randomized Patients Number Age Duration of OA (Years) Scale Pain Physical Functioning PGADS
N tot N Mean SD Mean SD Mean SD Mean SD Mean SD
Bensen [24] Placebo 12wk knee 1003 203 62.0 12.2 11.0 8.0 WOMAC Likert (pain 0-20, function 0-68) 10.7 4.7 36.1 14.7
celecoxib 100 mg 203 62.0 17.3 9.0 8.0 10.7 4.7 36.1 14.7
celecoxib 200 mg 197 62.0 13.3 10.0 8.0 10.7 4.7 36.1 14.5
celecoxib 400 mg 202 63.0 15.8 9.0 9.0 10.7 4.7 36.1 14.6
naproxen 1000mg 198 62.0 12.2 10.0 8.0 10.7 4.7 36.1 17.5
Birbara Study 1 [35] Placebo 6 wks knee 395 78 60.5 11.6 WOMAC VAS (0-100mm) 68.5 17.0 65.0 19.4
celecoxib 200 mg 157 61.3 9.2 68.3 17.0 67.5 17.5
Birbara Study 2 [35] Placebo 85 60.4 11.2 WOMAC VAS (0-100mm) 68.7 17.6 65.1 19.4
celecoxib 200 mg 169 60.7 11.2 66.8 17.3 63.1 19.8
Case [36] Placebo 12 wks knee 82 28 61.7 9.0 WOMAC VAS 198.6 110.9 697.1 375.2
aceta.phen.4000mg 29 62.1 11.4 210.8 86.3 657.0 262.5
diclofenac 150 mg 25 62.9 7.6 199.8 101.5 669.3 371.6
Fleischmann [27] Placebo 13 wks knee 1608 231 61.5 11.7 6.6 7.0 WOMAC Likert (pain 0-20, function 0-68) 9.9 3.3 33.0 8.5
lumiracoxib200 mg 462 61.1 11.1 6.1 7.2 10.3 3.2 32.0 8.3
lumiracoxib400 mg 463 60.8 11.5 6.4 7.0 9.9 3.4 33.7 8.6
celecoxib 200 mg 444 61.3 11.1 6.7 8.1 10.3 3.3 33.0 8.7
Geba [34] acetaminph.4000 mg 6 wks knee 382 94 63.1 10.9 WOMAC VAS (0-100mm)
celecoxib200 mg 97 62.6 11.0
Gibofsky [25] placebo150 mg 6 wks knee 475 96 63.1 9.9 8.3 7.9 WOMAC Likert (pain 0-20, function 0-68) 11.0 0.3 38.4 1.0
celecoxib 200 mg 189 62.2 10.5 8.6 8.1 11.2 0.3 38.8 0.8
Kivitz [31] Placebo 12 wks hip 1061 218 64.0 7.9 WOMAC Likert (pain 0-20, function 0-68) 10.5 7.2 35.3 14.7
celecoxib 100 mg 216 65.0 7.3 10.5 7.2 33.8 14.7
celecoxib200 mg 207 65.0 7.2 10.5 7.0 35.3 14.4
celecoxib 400 mg 213 67.0 6.9 10.8 7.1 34.5 14.6
naproxen 1000 mg 207 66.0 7.3 10.5 7.0 34.5 14.4
Lehmann [39] placebo 13 wks knee 1684 424 61.7 10.2 3.9 5.4 WOMAC Likert (pain 0-20, function 0-68) 9.8 3.2 35.8 10.8
lumiracoxib 100 mg 420 62.2 10.0 4.4 5.7 9.9 3.2 35.3 11.5
celecoxib 200 mg 420 62.9 10.5 4.4 6.2 10.2 3.2 36.2 10.8
Lisse [38] placebo 12 knee+hip 768 188 74.4 3.9 9.4 10.2 WOMAC Likert (pain 0-20, function 0-68) 9.9 3.2 33.6 11.3
celecoxib 200mg 191 75.0 4.0 10.0 8.9 10.3 3.3 35.0 10.7
celecoxib 400mg 183 75.0 4.0 10.3 9.6 10.3 3.2 35.5 11.1
naproxen 1000 mg 206 75.0 4.1 10.4 10.7 10.4 3.4 34.5 11.1
McKenna [40] placebo 6wks knee 600 200 60.5 34-88 WOMAC Likert (pain 0-20, function 0-68) 10.7 3.3 37.4 11.9
celecoxib 200 mg 201 63.0 32-85 10.6 3.1 37.4 10.4
diclofenac 150 mg 199 63.0 29-87 10.7 3.1 37.5 10.4
Miceli-Richard [32] placebo 6 wks knee 779 374 70.0 11.0 3.8 4.0 WOMAC VAS (0-100mm) 69.0 17.0 54.0 15.0
acetaminph.4000 mg 405 69.0 12.0 3.8 3.8 66.7 18.0 54.0 15.0
Schnitzer [33] Placebo 4 wks knee+hip 484 97 61.5 9.3 8.0 WOMAC Likert (pain 0-20, function 0-68) 9.6 3.5 32.7 10.4 62.5 18.1
lumiracoxib 100 mg 98 61.3 8.5 7.4 9.8 3.6 31.8 12.1 63.1 17.5
lumiracoxib 200 mg 96 59.8 9.4 6.6 9.6 3.0 31.1 11.3 62.0 18.5
lumiracoxib 400 mg 2*dd 99 59.6 9.9 6.9 9.6 3.7 31.5 11.8 64.0 17.3
diclofenac 150 mg 94 59.7 8.6 6.3 9.5 3.4 31.1 12.6 62.2 16.2
Sheldon [28] Placebo 13 wks knee 1551 382 60.8 10.5 7.0 7.4 WOMAC Likert (pain 0-20, function 0-68) 11.0 2.9 37.2 10.5
lumiracoxib 100 mg 391 60.2 11.1 6.9 7.7 10.8 3.1 37.3 9.8
celecoxib 200 mg 393 60.2 10.5 6.7 7.5 10.8 3.2 36.9 11.0
Smugar Study 1 [26] Placebo 6 wks knee+hip 1521 150 61.8 WOMAC VAS (0-100mm)
celecoxib 200 mg 456 61.8
Smugar Study 2 [26] placebo 150 mg knee+hip 1082 151 62.5 WOMAC VAS (0-100mm)
celecoxib 200 mg 460 62.0
Tannenbaum [29] Placebo 13 wks knee 1702 243 64.6 9.9 4.3 WOMAC Likert (pain 0-20, function 0-68) 10.3 3.0 34.6 10.4
lumiracoxib 200 mg 487 64.1 10.7 4.2 10.1 3.4 34.6 11.2
lumiracoxib 400 mg 491 64.3 10.4 5.2 10.0 3.3 33.9 11.4
celecoxib 200 mg 481 64.1 10.4 5.3 10.1 3.3 34.4 11.7
Williams [41] Placebo 6 wks knee 686 232 62.6 11.3 8.6 8.2 WOMAC Likert (pain 0-20, function 0-68) 10.3 3.5 34.9 12.0
celecoxib 200mg QD 223 62.7 10.9 8.8 7.7 10.2 3.7 34.3 12.2
Williams [42] Placebo 6 wk knee 718 244 61.3 11.6 9.7 8.7 WOMAC Likert (pain 0-20, function 0-68) 10.5 3.3 37.5 11.2
celecoxib 200mg (QD) 231 61.3 12.2 9.4 8.1 10.1 3.5 35.9 11.9
p007 [44] Placebo 14 wks knee 617 60 62.5 9.8 7.2 6.8 WOMAC VAS [0-100mm] 71.3 70.9 70.4
etoricoxib 30 mg 102 61.3 10.7 8.9 7.9 67.6 65.6 66.3
etoricoxib 60 mg 112 60.0 9.6 7.6 6.9 66.4 63.7 64.7
P018 placebo 12 wks knee+hip 496 56 7.9 7.2 WOMAC VAS [0-100mm] 71.1 68.0 71.8
etoricoxib 60 mg 222 7.1 6.9 68.9 66.4 67.6
naproxen 1000 mg 218 7.3 8.4 69.0 66.2 68.7
p019 [45] placebo 12 wks knee+hip 501 56 64.1 8.9 6.3 6.4 WOMAC VAS [0-100mm] 68.7 69.0 73.6
etoricoxib 60 mg 224 62.9 9.2 5.9 6.0 64.9 64.0 66.9
naproxen 1000 mg 221 63.2 9.3 6.3 6.5 65.7 63.7 67.8
P071 [43] Placebo 12 wks knee+hip 528 104 59.5 8.4 6.9 6.8 WOMAC VAS [0-100mm] 69.5 70.1 72.6
Etoricoxib 30 mg 214 63.1 10.6 7.9 8.6 68.7 68.1 72.2
Ibuprofen 2400 mg 210 61.3 9.6 8.2 7.7 67.8 67.8 70.5
P073 [47] Placebo 12 wks knee+hip 548 111 64.0 10.1 6.5 6.6 WOMAC VAS [0-100mm] 64.7 64.2 66.9
Etoricoxib 30 mg 224 62.1 9.0 6.6 7.3 66.5 64.3 70.1
Ibuprofen 2400 mg 213 62.3 9.6 6.7 8.1 64.7 62.5 69.9
P076 [48] Placebo 12 wks knee+hip 599 127 62.8 9.7 9.0 8.7 WOMAC VAS [0-100mm] 66.6 64.7 69.1
Etoricoxib 30mg 231 62.1 10.2 8.6 8.9 67.4 65.5 72.2
Celecoxib 200mg 241 62.5 9.3 8.4 8.7 67.5 66.6 71.3
P077 [48] Placebo 12 wks knee+hip 608 117 60.9 8.6 7.2 6.6 WOMAC VAS [0-100mm] 66.4 65.2 72.3
Etoricoxib 30mg 243 61.9 9.6 7.8 8.3 68.7 67.7 73.0
Celecoxib 200mg 247 62.2 9.5 8.3 8.7 67.3 65.8 70.1
Schnitzer [37] acetaminph. 4000 mg 6 wks knee 1578 269 61.9 10.7 WOMAC VAS [0-100mm]
celecoxib 200 mg 523 61.4 9.9
Hawel [30] dexibuprofen800 mg 15 days hip 148 74 55.3 10.1 WOMAC LIKERT [pain 0-20, function 0-68] 10.5 2.3 36.9 7.8
celecoxib200mg 74 53.2 9.4 10.4 2.4 36.8 9.6
805-01 [46] etoricoxib 60 mg 6 wks knee+hip 516 256 63.1 9.7 7.5 6.8 WOMAC VAS [0-100mm] 62.8 17.0 62.7 18.2 70.7 17.2
Diclofenac-sodium 150 mg 260 63.0 9.8 7.5 6.6 62.0 17.5 59.9 18.5 69.0 17.1