|
Length
of
Double
Blind
TX
Period |
Joints |
Randomized
Patients
Number |
Age |
Duration
of
OA
(Years) |
Scale |
Pain |
Physical
Functioning |
PGADS |
|
|
N tot |
N |
Mean |
SD |
Mean |
SD |
|
Mean |
SD |
Mean |
SD |
Mean |
SD |
Bensen
[24] |
Placebo |
12wk |
knee |
1003 |
203 |
62.0 |
12.2 |
11.0 |
8.0 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
10.7 |
4.7 |
36.1 |
14.7 |
|
|
celecoxib 100 mg |
203 |
62.0 |
17.3 |
9.0 |
8.0 |
10.7 |
4.7 |
36.1 |
14.7 |
|
|
celecoxib 200 mg |
197 |
62.0 |
13.3 |
10.0 |
8.0 |
10.7 |
4.7 |
36.1 |
14.5 |
|
|
celecoxib 400 mg |
202 |
63.0 |
15.8 |
9.0 |
9.0 |
10.7 |
4.7 |
36.1 |
14.6 |
|
|
naproxen 1000mg |
198 |
62.0 |
12.2 |
10.0 |
8.0 |
10.7 |
4.7 |
36.1 |
17.5 |
|
|
Birbara
Study 1
[35] |
Placebo |
6 wks |
knee |
395 |
78 |
60.5 |
11.6 |
|
|
WOMAC
VAS
(0-100mm) |
68.5 |
17.0 |
65.0 |
19.4 |
|
|
celecoxib 200 mg |
157 |
61.3 |
9.2 |
|
|
68.3 |
17.0 |
67.5 |
17.5 |
|
|
Birbara
Study 2
[35] |
Placebo |
|
|
|
85 |
60.4 |
11.2 |
|
|
WOMAC
VAS
(0-100mm) |
68.7 |
17.6 |
65.1 |
19.4 |
|
|
celecoxib 200 mg |
169 |
60.7 |
11.2 |
|
|
66.8 |
17.3 |
63.1 |
19.8 |
|
|
Case
[36] |
Placebo |
12 wks |
knee |
82 |
28 |
61.7 |
9.0 |
|
|
WOMAC
VAS |
198.6 |
110.9 |
697.1 |
375.2 |
|
|
aceta.phen.4000mg |
29 |
62.1 |
11.4 |
|
|
210.8 |
86.3 |
657.0 |
262.5 |
|
|
diclofenac 150 mg |
25 |
62.9 |
7.6 |
|
|
199.8 |
101.5 |
669.3 |
371.6 |
|
|
Fleischmann
[27] |
Placebo |
13 wks |
knee |
1608 |
231 |
61.5 |
11.7 |
6.6 |
7.0 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
9.9 |
3.3 |
33.0 |
8.5 |
|
|
lumiracoxib200 mg |
462 |
61.1 |
11.1 |
6.1 |
7.2 |
10.3 |
3.2 |
32.0 |
8.3 |
|
|
lumiracoxib400 mg |
463 |
60.8 |
11.5 |
6.4 |
7.0 |
9.9 |
3.4 |
33.7 |
8.6 |
|
|
celecoxib 200 mg |
444 |
61.3 |
11.1 |
6.7 |
8.1 |
10.3 |
3.3 |
33.0 |
8.7 |
|
|
Geba
[34] |
acetaminph.4000 mg |
6 wks |
knee |
382 |
94 |
63.1 |
10.9 |
|
|
WOMAC
VAS
(0-100mm) |
|
|
|
|
|
|
celecoxib200 mg |
97 |
62.6 |
11.0 |
|
|
|
|
|
|
|
|
Gibofsky
[25] |
placebo150 mg |
6 wks |
knee |
475 |
96 |
63.1 |
9.9 |
8.3 |
7.9 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
11.0 |
0.3 |
38.4 |
1.0 |
|
|
celecoxib 200 mg |
189 |
62.2 |
10.5 |
8.6 |
8.1 |
11.2 |
0.3 |
38.8 |
0.8 |
|
|
Kivitz
[31] |
Placebo |
12 wks |
hip |
1061 |
218 |
64.0 |
|
7.9 |
|
WOMAC
Likert
(pain 0-20,
function 0-68) |
10.5 |
7.2 |
35.3 |
14.7 |
|
|
celecoxib 100 mg |
216 |
65.0 |
|
7.3 |
|
10.5 |
7.2 |
33.8 |
14.7 |
|
|
celecoxib200 mg |
207 |
65.0 |
|
7.2 |
|
10.5 |
7.0 |
35.3 |
14.4 |
|
|
celecoxib 400 mg |
213 |
67.0 |
|
6.9 |
|
10.8 |
7.1 |
34.5 |
14.6 |
|
|
naproxen 1000 mg |
207 |
66.0 |
|
7.3 |
|
10.5 |
7.0 |
34.5 |
14.4 |
|
|
Lehmann
[39] |
placebo |
13 wks |
knee |
1684 |
424 |
61.7 |
10.2 |
3.9 |
5.4 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
9.8 |
3.2 |
35.8 |
10.8 |
|
|
lumiracoxib 100 mg |
420 |
62.2 |
10.0 |
4.4 |
5.7 |
9.9 |
3.2 |
35.3 |
11.5 |
|
|
celecoxib 200 mg |
420 |
62.9 |
10.5 |
4.4 |
6.2 |
10.2 |
3.2 |
36.2 |
10.8 |
|
|
Lisse
[38] |
placebo |
12 |
knee+hip |
768 |
188 |
74.4 |
3.9 |
9.4 |
10.2 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
9.9 |
3.2 |
33.6 |
11.3 |
|
|
celecoxib 200mg |
191 |
75.0 |
4.0 |
10.0 |
8.9 |
10.3 |
3.3 |
35.0 |
10.7 |
|
|
celecoxib 400mg |
183 |
75.0 |
4.0 |
10.3 |
9.6 |
10.3 |
3.2 |
35.5 |
11.1 |
|
|
naproxen 1000 mg |
206 |
75.0 |
4.1 |
10.4 |
10.7 |
10.4 |
3.4 |
34.5 |
11.1 |
|
|
McKenna
[40] |
placebo |
6wks |
knee |
600 |
200 |
60.5 |
34-88 |
|
|
WOMAC
Likert
(pain 0-20,
function 0-68) |
10.7 |
3.3 |
37.4 |
11.9 |
|
|
celecoxib 200 mg |
201 |
63.0 |
32-85 |
|
|
10.6 |
3.1 |
37.4 |
10.4 |
|
|
diclofenac 150 mg |
199 |
63.0 |
29-87 |
|
|
10.7 |
3.1 |
37.5 |
10.4 |
|
|
Miceli-Richard
[32] |
placebo |
6 wks |
knee |
779 |
374 |
70.0 |
11.0 |
3.8 |
4.0 |
WOMAC
VAS
(0-100mm) |
69.0 |
17.0 |
54.0 |
15.0 |
|
|
acetaminph.4000 mg |
405 |
69.0 |
12.0 |
3.8 |
3.8 |
66.7 |
18.0 |
54.0 |
15.0 |
|
|
Schnitzer
[33] |
Placebo |
4 wks |
knee+hip |
484 |
97 |
61.5 |
9.3 |
8.0 |
|
WOMAC
Likert
(pain 0-20,
function 0-68) |
9.6 |
3.5 |
32.7 |
10.4 |
62.5 |
18.1 |
lumiracoxib 100 mg |
98 |
61.3 |
8.5 |
7.4 |
|
9.8 |
3.6 |
31.8 |
12.1 |
63.1 |
17.5 |
lumiracoxib 200 mg |
96 |
59.8 |
9.4 |
6.6 |
|
9.6 |
3.0 |
31.1 |
11.3 |
62.0 |
18.5 |
lumiracoxib 400 mg 2*dd |
99 |
59.6 |
9.9 |
6.9 |
|
9.6 |
3.7 |
31.5 |
11.8 |
64.0 |
17.3 |
diclofenac 150 mg |
94 |
59.7 |
8.6 |
6.3 |
|
9.5 |
3.4 |
31.1 |
12.6 |
62.2 |
16.2 |
Sheldon
[28] |
Placebo |
13 wks |
knee |
1551 |
382 |
60.8 |
10.5 |
7.0 |
7.4 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
11.0 |
2.9 |
37.2 |
10.5 |
|
|
lumiracoxib 100 mg |
391 |
60.2 |
11.1 |
6.9 |
7.7 |
10.8 |
3.1 |
37.3 |
9.8 |
|
|
celecoxib 200 mg |
393 |
60.2 |
10.5 |
6.7 |
7.5 |
10.8 |
3.2 |
36.9 |
11.0 |
|
|
Smugar
Study 1
[26] |
Placebo |
6 wks |
knee+hip |
1521 |
150 |
61.8 |
|
|
|
WOMAC
VAS
(0-100mm) |
|
|
|
|
|
|
celecoxib 200 mg |
456 |
61.8 |
|
|
|
|
|
|
|
|
|
Smugar
Study 2
[26] |
placebo 150 mg |
|
knee+hip |
1082 |
151 |
62.5 |
|
|
|
WOMAC
VAS
(0-100mm) |
|
|
|
|
|
|
celecoxib 200 mg |
460 |
62.0 |
|
|
|
|
|
|
|
|
|
Tannenbaum
[29] |
Placebo |
13 wks |
knee |
1702 |
243 |
64.6 |
9.9 |
4.3 |
|
WOMAC
Likert
(pain 0-20,
function 0-68) |
10.3 |
3.0 |
34.6 |
10.4 |
|
|
lumiracoxib 200 mg |
487 |
64.1 |
10.7 |
4.2 |
|
10.1 |
3.4 |
34.6 |
11.2 |
|
|
lumiracoxib 400 mg |
491 |
64.3 |
10.4 |
5.2 |
|
10.0 |
3.3 |
33.9 |
11.4 |
|
|
celecoxib 200 mg |
481 |
64.1 |
10.4 |
5.3 |
|
10.1 |
3.3 |
34.4 |
11.7 |
|
|
Williams
[41] |
Placebo |
6 wks |
knee |
686 |
232 |
62.6 |
11.3 |
8.6 |
8.2 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
10.3 |
3.5 |
34.9 |
12.0 |
|
|
celecoxib 200mg QD |
223 |
62.7 |
10.9 |
8.8 |
7.7 |
10.2 |
3.7 |
34.3 |
12.2 |
|
|
Williams
[42] |
Placebo |
6 wk |
knee |
718 |
244 |
61.3 |
11.6 |
9.7 |
8.7 |
WOMAC
Likert
(pain 0-20,
function 0-68) |
10.5 |
3.3 |
37.5 |
11.2 |
|
|
celecoxib 200mg (QD) |
231 |
61.3 |
12.2 |
9.4 |
8.1 |
10.1 |
3.5 |
35.9 |
11.9 |
|
|
p007
[44] |
Placebo |
14 wks |
knee |
617 |
60 |
62.5 |
9.8 |
7.2 |
6.8 |
WOMAC
VAS
[0-100mm] |
71.3 |
|
70.9 |
|
70.4 |
|
etoricoxib 30 mg |
102 |
61.3 |
10.7 |
8.9 |
7.9 |
67.6 |
|
65.6 |
|
66.3 |
|
etoricoxib 60 mg |
112 |
60.0 |
9.6 |
7.6 |
6.9 |
66.4 |
|
63.7 |
|
64.7 |
|
P018 |
placebo |
12 wks |
knee+hip |
496 |
56 |
|
|
7.9 |
7.2 |
WOMAC
VAS
[0-100mm] |
71.1 |
|
68.0 |
|
71.8 |
|
etoricoxib 60 mg |
222 |
|
|
7.1 |
6.9 |
68.9 |
|
66.4 |
|
67.6 |
|
naproxen 1000 mg |
218 |
|
|
7.3 |
8.4 |
69.0 |
|
66.2 |
|
68.7 |
|
p019
[45] |
placebo |
12 wks |
knee+hip |
501 |
56 |
64.1 |
8.9 |
6.3 |
6.4 |
WOMAC
VAS
[0-100mm] |
68.7 |
|
69.0 |
|
73.6 |
|
etoricoxib 60 mg |
224 |
62.9 |
9.2 |
5.9 |
6.0 |
64.9 |
|
64.0 |
|
66.9 |
|
naproxen 1000 mg |
221 |
63.2 |
9.3 |
6.3 |
6.5 |
65.7 |
|
63.7 |
|
67.8 |
|
P071
[43] |
Placebo |
12 wks |
knee+hip |
528 |
104 |
59.5 |
8.4 |
6.9 |
6.8 |
WOMAC
VAS
[0-100mm] |
69.5 |
|
70.1 |
|
72.6 |
|
Etoricoxib 30 mg |
214 |
63.1 |
10.6 |
7.9 |
8.6 |
68.7 |
|
68.1 |
|
72.2 |
|
Ibuprofen 2400 mg |
210 |
61.3 |
9.6 |
8.2 |
7.7 |
67.8 |
|
67.8 |
|
70.5 |
|
P073
[47] |
Placebo |
12 wks |
knee+hip |
548 |
111 |
64.0 |
10.1 |
6.5 |
6.6 |
WOMAC
VAS
[0-100mm] |
64.7 |
|
64.2 |
|
66.9 |
|
Etoricoxib 30 mg |
224 |
62.1 |
9.0 |
6.6 |
7.3 |
66.5 |
|
64.3 |
|
70.1 |
|
Ibuprofen 2400 mg |
213 |
62.3 |
9.6 |
6.7 |
8.1 |
64.7 |
|
62.5 |
|
69.9 |
|
P076
[48] |
Placebo |
12 wks |
knee+hip |
599 |
127 |
62.8 |
9.7 |
9.0 |
8.7 |
WOMAC
VAS
[0-100mm] |
66.6 |
|
64.7 |
|
69.1 |
|
Etoricoxib 30mg |
231 |
62.1 |
10.2 |
8.6 |
8.9 |
67.4 |
|
65.5 |
|
72.2 |
|
Celecoxib 200mg |
241 |
62.5 |
9.3 |
8.4 |
8.7 |
67.5 |
|
66.6 |
|
71.3 |
|
P077
[48] |
Placebo |
12 wks |
knee+hip |
608 |
117 |
60.9 |
8.6 |
7.2 |
6.6 |
WOMAC
VAS
[0-100mm] |
66.4 |
|
65.2 |
|
72.3 |
|
Etoricoxib 30mg |
243 |
61.9 |
9.6 |
7.8 |
8.3 |
68.7 |
|
67.7 |
|
73.0 |
|
Celecoxib 200mg |
247 |
62.2 |
9.5 |
8.3 |
8.7 |
67.3 |
|
65.8 |
|
70.1 |
|
Schnitzer
[37] |
acetaminph. 4000 mg |
6 wks |
knee |
1578 |
269 |
61.9 |
10.7 |
|
|
WOMAC
VAS
[0-100mm] |
|
|
|
|
|
|
celecoxib 200 mg |
523 |
61.4 |
9.9 |
|
|
|
|
|
|
|
|
Hawel
[30] |
dexibuprofen800 mg
|
15 days |
hip |
148 |
74 |
55.3 |
10.1 |
|
|
WOMAC
LIKERT
[pain 0-20,
function 0-68] |
10.5 |
2.3 |
36.9 |
7.8 |
|
|
celecoxib200mg
|
74 |
53.2 |
9.4 |
|
|
10.4 |
2.4 |
36.8 |
9.6 |
|
|
805-01
[46] |
etoricoxib 60 mg |
6 wks |
knee+hip |
516 |
256 |
63.1 |
9.7 |
7.5 |
6.8 |
WOMAC VAS
[0-100mm] |
62.8 |
17.0 |
62.7 |
18.2 |
70.7 |
17.2 |
Diclofenac-sodium 150 mg |
260 |
63.0 |
9.8 |
7.5 |
6.6 |
62.0 |
17.5 |
59.9 |
18.5 |
69.0 |
17.1 |