Table 3: Overview of the Treatment Effects (Effect Sizes) Versus Placebo or Active Intervention by Study for Physical Function

Placebo Acetaminophen 4000 Naproxen 1000 Ibuprofen 2400 Dexibuprofen 800 Diclofenac 150 Celecoxib 100 Celecoxib 200 Celecoxib 400 Lumiracoxib 100 Lumiracoxib 200 Lumiracoxib 400 Etoricoxib 30 Etoricoxib 60
ES se ES se ES se ES se ES se ES se ES se ES se ES se ES se ES se ES se
Bensen [24] Ref -0.14 0.1 -0.1 0.1 -0.29 0.1 -0.2 0.1
Birbara Study 1 [35] Ref -0.15 0.14
Birbara Study 2 [35] Ref -0.15 0.13
Case [36] Ref 0.2 0.27 -0.36 0.28
Fleischmann [27] Ref -0.39 0.08 -0.49 0.08 -0.46 0.08
Geba [34]*** 0.24 0.15 Ref
Gibofsky [25] Ref -0.48 0.13
Kivitz [31] Ref -0.31 0.1 -0.19 0.1 -0.24 0.1 -0.25 0.1
Lehmann [39] Ref -0.19 0.07 -0.18 0.07
Lisse [38] Ref -0.31 0.1 -0.32 0.1 -0.32 0.1
McKenna [40] Ref -0.53 0.1 -0.4 0.1
Miceli-Richard [32] Ref 0.00 0.07
Schnitzer [33] Ref -0.38 0.15 -0.32 0.15 -0.17 0.15 -0.35 0.15
Sheldon [28] Ref -0.36 0.07 -0.45 0.07
Smugar study 1 [26] Ref -0.51 0.09
Smugar study 2 [26] Ref -0.64 0.1
Tannenbaum [29] Ref -0.26 0.08 -0.3 0.08 -0.28 0.08
Williams [41] Ref -0.26 0.09
Williams [42] Ref -0.2 0.09
P007 [35] Ref -0.59 0.17 -0.96 0.17
P018 [np] Ref -0.89 0.16 -0.79 0.15
P019 [45] Ref -0.42 0.15 -0.42 0.15
P071 [43] Ref -0.46 0.12 -0.5 0.12
P073 [47] Ref -0.36 0.12 -0.51 0.12
P076 [48] Ref -0.57 0.11 -0.72 0.11
P077 [48] Ref -0.61 0.12 -0.71 0.12
Schnitzer 2005*** [37] 0.24 0.08 Ref
Hawel [30]**** Ref 0.01 0.18
805-01***** [46] Ref -0.02 0.09

* ES=Effect size. small (ES ≥ 0.2), moderate (ES ≥ 0.5) or large ((ES ≥ 0.8). negative effect sizes indicate improvement
** se = standard error of the effect size.
*** versus celecoxib 200
**** versus dexibuprofen 800
***** versus diclofenac 150.