Fig. (1) In vivo experiments. (A) Nociception, evaluated at 0, 1, 3, 6 and 24 hours after i.a. injection. Each bars represents mean ± SEM (n= 7). *P < 0.05 on time 1, **P < 0.01 on times 3, 6 and 24 h versus vehicle treatment, by two-way analysis of variance (ANOVA) followed by the Tukey’s post hoc test. (B). Leucocyte migration into the articular cavity of the knee joint, assessed 48 hours after treatment with vehicle or AEGH [600 mg/kg orally, twice a day]. Injection of saline alone was used as negative control. Each bar represents mean ± SEM (n= 7). *P = 0.015 versus vehicle treatment, by Student’s unpaired t-test.