Fig. (2) Molecular models of HERV-K10/IgG1Fc epitopes. Epitopes A and B taken from Westwood  and modeled using PyMOL
(Molecular Graphics System, Version 1.2r3pre, Schrodinger, LLC: http://www.pymol.org/pymol) and enhanced using UCSF Chimera
(http://www.cgl.ucsf.edu/chimera). Molecular models were displayed in ‘mesh’ mode. Arrows point to amino acid residues highlighted and
displayed on an IgGFc molecule (PDB file: 3AVE) using UCSF Chimera. CH: constant heavy 2 and 3 domains of IgG. In B: despite the
amino acid substitution, there appears to be little change in molecular shape which may facilitate antibody cross-reactivity.